Background <p>The prevention of etiological factors for cardiovascular diseases is a critical contemporary health priority. A significant knowledge gap exists regarding robust studies that analyze cardiovascular risk factors through the lens of nursing diagnoses. Modeling these factors allows for the prioritization of variables that should be targeted in clinical care plans. This study contributes to the advancement of nursing practice and the development of structured care programs focused on cardiovascular risk. The objective was to develop exploratory models of etiological factors for cardiovascular diseases through a structured nursing follow-up program.</p> Methods <p>This clinical trial was conducted between 2023 and 2024. A total of 71 university students presenting etiological factors for NANDA-I diagnosis 00311 were recruited. The intervention consisted of nursing consultations facilitated by the e-TEORISC software compared to standard care. Data analysis was performed using regression models via the Forward Stepwise method.</p> Findings <p>The follow-up included 35 participants, primarily Brazilian, single, mixed-race, and male, with a mean age of 25 years. The resulting models elucidated the relationships between metabolic syndrome and female gender, HDL, and SBP; harmful alcohol consumption vs. fasting blood glucose; and understanding of cardiovascular risk factors vs. waist circumference (no risk), neck-to-thigh ratio (No risk), COVID-19 history (negative), LDL, and HDL.</p> Conclusion <p>The models suggest significant associations between various etiological factors and cardiovascular risk indicators among university students.</p> Clinical trial number <p>Brazilian Registry of Clinical Trials n° RBR-8y3qx39 e <i>Universal Trial Number</i> nº U1111-1293-7938 (date registered: 19/07/2023).</p>