Background <p>Initiatives to support nurses’ wellbeing and resilience aim to maintain their mental and emotional health amid workplace challenges. These programs foster positive emotions, which are key to building resilience. While some view coping ability as innate, others regard resilience as a skill that can be developed.</p> Objective <p>This study aimed to assess the impact of nurses’ resilience and wellbeing programs in different contexts and how they affect patient’s care and organizational operations.</p> Methods <p>Online English articles published on PsycINFO, Scopus, PubMed, CINAHL, and ProQuest only included using the Whittemore &amp; Knafl, 2005 framework from January 2005 to January 2020 were used to write and complete this study. Relevant data were extracted using a structured approach to ensure consistency and accuracy across studies. Additionally, the quality of each included study was assessed using established PRISMA appraisal tools to evaluate methodological rigor and minimize the risk of bias.</p> Results <p>The literature review included 19 articles; of which 3 were mixed-method studies, 14 were quantitative studies, and two were qualitative studies. This review classified the 19 articles into three themes on impact: (1) Impact on nurses, (2) impact on patients’ care, and (3) impact on organizations and work environment.</p> Conclusions <p>To ensure the success of resilience and wellbeing interventions, overall, leaders should adopt an organizational approach. Programs should combine resilience and wellbeing with healthcare institutions’ overall wellbeing plans as part of a comprehensive staff support approach. These programs should be evaluated in a different cultural context to assess the impact and the effect on a short and long team on the nurse’s wellbeing.</p>