Background <p>Nursing interns frequently experience transition shock. Transition is a complex and continuously shifting process that involves vital changes in roles, responsibilities, and goals as one phase ends and another begins.</p> Aim <p>The purpose of the study was to investigate the effect of a transition training program on work engagement among nurse interns.</p> Methods <p>Using a quasi-experimental design consisting of a single-group pretest, posttest, and follow-up test, the study was carried out at the Cairo, Egypt-affiliated Ain-Shams University Hospital, El-Demerdash Hospital, Pediatrics Hospital, and Cardiovascular Hospital. A simple random sampling technique was used, including 160 nurse interns. Data were gathered using three instruments: the nurse interns’ transition knowledge questionnaire, the Casey-Fink Graduate Nurse Experience Survey, and the Utrecht Work Engagement Scale.</p> Results <p>The nurse interns’ transition knowledge, experience, and work engagement showed significant improvement in post-implantation training program. Post-training; the majority of nurse interns’ had satisfactory knowledge with some decline at follow-up phase. Also, the majority of nurse interns’ had satisfactory transition experience with some decline at follow up phase. Additionally, post training the most of nurse interns had high level of work engagement with some decline at follow-up phase.</p> Conclusion <p>The knowledge, transition experience, and work engagement of nursing interns significantly improved following the implementation of the transition training program. To fill the gaps in clinical preparation, competency development, and the transition to professional practice, nursing education programs should implement structured internship curricula that combine academic knowledge with a variety of clinical experiences.</p> Clinical trial number <p>Not applicable.</p>