Scholarlink

Background <p>Infusion-related adverse reactions to azithromycin, though uncommon, can pose serious risks in pediatric care, warranting focused attention from nursing professionals. Pediatric nurses are key to early identification and intervention, but their knowledge, attitude, and practice (KAP) regarding such events remain unclear.</p> Methods <p>We conducted a cross-sectional survey among 835 pediatric nurses from 53 hospitals in Zhejiang Province, China. A custom-designed, expert-reviewed questionnaire assessed demographic characteristics, azithromycin-related knowledge, attitudes, and practices. Confirmatory factor analysis (CFA) and reliability testing (Cronbach’s alpha) were used to evaluate the instrument’s validity. Mediation analysis was performed to examine the indirect effects of knowledge and job satisfaction on practice, with attitude as a mediator.</p> Results <p>The CFA indicated acceptable model fit (RMSEA = 0.043; CFI = 0.892), and internal consistency was moderate to good across domains (α = 0.637–0.84). Nurses demonstrated moderate knowledge (mean score 13.59/20), constructive attitudes (28.43/35), and high levels of self-reported practice (42.30/50). Job satisfaction and 5–8 years of experience were associated with better attitudes and practices. Mediation analysis revealed that knowledge (β = 0.11, <i>P</i> = 0.034) and job satisfaction (β = 0.49, <i>P</i> &lt; 0.001) directly influenced attitude, which in turn mediated their effects on practice. Knowledge had only an indirect effect on practice (β = 0.04, <i>P</i> = 0.042), underscoring the importance of attitudinal reinforcement.</p> Conclusions <p>Pediatric nurses possess limited pharmacological knowledge but exhibit safe infusion practices, likely driven by standard protocols and clinical experience. Educational interventions should go beyond factual training to include attitude-shaping strategies. Hospitals should prioritize structured in-service programs, simulation-based learning, and pre-infusion checklists to enhance safety. Future large-scale, multi-center, and longitudinal studies across diverse regions are warranted to validate these findings and enhance their generalizability.</p> Clinical trial number <p>Not applicable.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Knowledge, attitude, and practice toward azithromycin infusion reactions among pediatric nurses: a cross-sectional study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月1日

查看全文
  • Linlin Wei,
  • Jianying Xu,
  • Chaolang Zhang,
  • Cuiying Chen,
  • Jia Chen

摘要

Background

Infusion-related adverse reactions to azithromycin, though uncommon, can pose serious risks in pediatric care, warranting focused attention from nursing professionals. Pediatric nurses are key to early identification and intervention, but their knowledge, attitude, and practice (KAP) regarding such events remain unclear.

Methods

We conducted a cross-sectional survey among 835 pediatric nurses from 53 hospitals in Zhejiang Province, China. A custom-designed, expert-reviewed questionnaire assessed demographic characteristics, azithromycin-related knowledge, attitudes, and practices. Confirmatory factor analysis (CFA) and reliability testing (Cronbach’s alpha) were used to evaluate the instrument’s validity. Mediation analysis was performed to examine the indirect effects of knowledge and job satisfaction on practice, with attitude as a mediator.

Results

The CFA indicated acceptable model fit (RMSEA = 0.043; CFI = 0.892), and internal consistency was moderate to good across domains (α = 0.637–0.84). Nurses demonstrated moderate knowledge (mean score 13.59/20), constructive attitudes (28.43/35), and high levels of self-reported practice (42.30/50). Job satisfaction and 5–8 years of experience were associated with better attitudes and practices. Mediation analysis revealed that knowledge (β = 0.11, P = 0.034) and job satisfaction (β = 0.49, P < 0.001) directly influenced attitude, which in turn mediated their effects on practice. Knowledge had only an indirect effect on practice (β = 0.04, P = 0.042), underscoring the importance of attitudinal reinforcement.

Conclusions

Pediatric nurses possess limited pharmacological knowledge but exhibit safe infusion practices, likely driven by standard protocols and clinical experience. Educational interventions should go beyond factual training to include attitude-shaping strategies. Hospitals should prioritize structured in-service programs, simulation-based learning, and pre-infusion checklists to enhance safety. Future large-scale, multi-center, and longitudinal studies across diverse regions are warranted to validate these findings and enhance their generalizability.

Clinical trial number

Not applicable.