Objective <p>This study aims to investigate the factors contributing to kinesiophobia in patients following percutaneous coronary intervention (PCI).</p> Methods <p>Purposive sampling was employed to conduct semi-structured interviews with 14 patients and 4 healthcare professionals who satisfied the inclusion and exclusion criteria, from May 2023 to June 2023. Data were coded, categorized, and thematically analyzed using the Colaizzi seven-step analysis method.</p> Results <p>The factors contributing to kinesiophobia in patients post-PCI were classified into four primary themes: heightened psychological stress, increased uncertainty regarding exercise, reduced self-efficacy, and inadequate support systems.</p> Conclusion <p>Kinesiophobia in patients post-PCI hinders adherence to cardiac rehabilitation protocols. Early identification and analysis of the factors contributing to kinesiophobia can guide the development and implementation of effective intervention strategies.</p> Clinical registration number <p>Not applicable.</p>