Background <p>Nursing prescribing rights have been proposed in many countries, with physicians’ attitudes playing an important role. This study aimed to investigate the attitudes of physicians toward nurse prescribing rights.</p> Methods <p>A cross-sectional study of 112 Chinese physicians was conducted from January to March 2024. This study utilized a demographic information form, nurses’ prescription right knowledge questions, and a scale to measure nurse-physician collaboration. The data was analyzed with IBM SPSS-21 software using descriptive and inferential statistics. We used the mean±standard deviation, frequencies and percentages to describe the demographic information, T-test, Chi-square test or Fisher’ s exact test, and binary logistic regression analysis to analyze the correlated factors of the attitudes of physicians toward nurse prescribing rights.</p> Results <p>Of 112 physicians, 60 supported nurse prescribing rights, accounting for 53.57% of the total. The results of the single-factor analysis indicated significant differences in the aspects of sex. The binary logistic regression revealed that being female (OR = 0.195, 95%CI = 0.072 ∼ 0.529), having knowledge of nurse prescribing rights (OR = 1.513, 95%CI = 1.051 ∼ 2.176), and promoting nurse-physician collaboration (OR = 1.058, 95%CI = 1.032 ∼ 1.084) were the factors that correlated with physicians’ attitudes toward nurse prescribing rights.</p> Conclusions <p>Most physicians expressed a favorable attitude toward nurse prescribing rights. The results of this study will help advance the development of nurse prescribing rights and ultimately improve the quality of patient care.</p>