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Background <p>Xenotransplantation using genetically edited pig organs has been considered a promising solution to the global organ shortage. However, its successful implementation depends not only on scientific advance but also on public acceptance. Empirical evidence on public awareness, acceptance, and ethical concerns regarding xenotransplantation in China remains scarce. This study was conducted to investigate public familiarity with xenotransplantation, acceptance of the technology, and factors associated with acceptance.</p> Methods <p>A cross-sectional survey was conducted among adults in mainland China based on a structured questionnaire. A convenience sampling strategy was adopted. Data regarding demographic characteristics, familiarity with xenotransplantation, acceptance under a life-saving scenario, religious considerations, and perceived impact on human organ donation were collected. Descriptive statistics, binary logistic regression, and ordinal logistic regression were used for analysis.</p> Results <p>A total of 589 valid questionnaires were analyzed. The majority of respondents (85.57%) had at least heard of xenotransplantation, although only 4.92% reported being very familiar. In a hypothetical life-saving scenario, 36.67% reported they would definitely accept xenotransplantation, while 11.54% would definitely not. Acceptance was higher among males, younger adults, medical workers, and those familiar with the technology, and lower among individuals with higher education or perceived religious conflict. Perceived religious conflict was significantly associated with acceptance (OR = 0.22, <i>p</i> &lt; 0.01). Respondents with more optimistic expectations of xenotransplantation were more likely to perceive that it would weaken willingness to donate human organs (OR = 5.49, <i>p</i> &lt; 0.01). The main public concerns included clinical trial safety (75%), postoperative outcomes (74%), and costs (63%).</p> Conclusions <p>Public familiarity with xenotransplantation in China remains limited, and acceptance is shaped by sociodemographic factors, religious beliefs, and familiarity with the technology. Transparent risk communication, culturally sensitive public engagement, and stratified information strategies are required to support responsible clinical translation into practice and ethical governance of xenotransplantation.</p>

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Public awareness and acceptance of xenotransplantation in China: a cross-sectional survey

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月6日

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  • Jing Wen,
  • Haoran Li,
  • Di Wang,
  • Mingtao Huang,
  • Xiaomei Zhai

摘要

Background

Xenotransplantation using genetically edited pig organs has been considered a promising solution to the global organ shortage. However, its successful implementation depends not only on scientific advance but also on public acceptance. Empirical evidence on public awareness, acceptance, and ethical concerns regarding xenotransplantation in China remains scarce. This study was conducted to investigate public familiarity with xenotransplantation, acceptance of the technology, and factors associated with acceptance.

Methods

A cross-sectional survey was conducted among adults in mainland China based on a structured questionnaire. A convenience sampling strategy was adopted. Data regarding demographic characteristics, familiarity with xenotransplantation, acceptance under a life-saving scenario, religious considerations, and perceived impact on human organ donation were collected. Descriptive statistics, binary logistic regression, and ordinal logistic regression were used for analysis.

Results

A total of 589 valid questionnaires were analyzed. The majority of respondents (85.57%) had at least heard of xenotransplantation, although only 4.92% reported being very familiar. In a hypothetical life-saving scenario, 36.67% reported they would definitely accept xenotransplantation, while 11.54% would definitely not. Acceptance was higher among males, younger adults, medical workers, and those familiar with the technology, and lower among individuals with higher education or perceived religious conflict. Perceived religious conflict was significantly associated with acceptance (OR = 0.22, p < 0.01). Respondents with more optimistic expectations of xenotransplantation were more likely to perceive that it would weaken willingness to donate human organs (OR = 5.49, p < 0.01). The main public concerns included clinical trial safety (75%), postoperative outcomes (74%), and costs (63%).

Conclusions

Public familiarity with xenotransplantation in China remains limited, and acceptance is shaped by sociodemographic factors, religious beliefs, and familiarity with the technology. Transparent risk communication, culturally sensitive public engagement, and stratified information strategies are required to support responsible clinical translation into practice and ethical governance of xenotransplantation.