Background <p>Research is limited as to how physical and mental symptoms may relate to emotional social support in health profession students, who often experience social isolation. The ORBIT Model Phase Ia was used to guide this proof-of-concept study. </p> Methods <p>Surveys were distributed at two timepoints to preclinical medical, dental, veterinary, and physical therapy students at a health sciences university. Surveys included the Perceived Stress Scale, the Generalized Anxiety Disorder scale, the Patient Health Questionnaire scales for depression and somatization, and the NIH Toolbox: Emotional Social Support subscale. </p> Results <p><i>N</i> = 38 separate individuals completed the timepoints. The outcome measures appeared tolerable and acceptable to the participants at two time-points. Emotional social support was below recommended levels, particularly among Hispanic/Latino students. Social support was significantly negatively correlated with perceived stress (<i>rho</i> = -0.43, <i>p</i> &lt; 0.01), anxiety (<i>rho</i> = -0.34, <i>p</i> &lt; 0.01), and depression (<i>rho</i> = -0.40, <i>p</i> &lt; 0.01) at T1, and depression (<i>rho</i> = -0.43, <i>p</i> &lt; 0.01) and physical symptoms (<i>rho</i> = -0.46, <i>p</i> &lt; 0.01) at T2. </p> Conclusions <p>Results support proof-of-concept for an association between these variables in health profession students. Further investigation into emotional support among health profession students in a larger sample is warranted.</p>