Background <p>Opportunities for nurses, midwives, allied health professionals and healthcare scientists (NMAHP+s) to engage in research are increasing but still lag behind opportunities for medical staff.Iinitiatives to identify, support and develop NMAHP+s considering and pursuing clinical academic roles are key to growing an NMAHP+ clinical academic workforce. We describe and evaluate the impact of the Interdisciplinary Clinical Academic health Research Excellence facilitated research career pathway (iCAhRE^™ programme) on NMAHP+ participants in one National Health Service Trust in England.</p> Methods <p>The study used a mixed methods approach informed by the Kirkpatrick Model of Training/Evaluation. Quantitative data related to uptake, progression through programme stages and key demographics of participants in the programme. Twenty-nine participants participated in a survey which assessed experiences of the programme, learning and impact from the programme, career trajectories, and barriers and enablers to pursuing a clinical academic career. Experiences of the programme were captured in greater depth in 12 interviews.</p> Results <p>Since 2016, participants were able to engage with the programme appropriate to their needs and research careers. Responses to the programme were highly positive and participants had increased their research knowledge and skills, initiated new research-related activities, improved their practice and increased their confidence. A high number had progressed to a role with a higher banding compared to when they started the programme (37.9%) and had research as part of their current role (55.2%). However, significant challenges to pursuing a clinical academic career for NMAHP+s included: unsupportive managers, lack of dedicated time for research engagement in a context of clinical pressures, a lack of clinical academic posts and limited progression opportunities.</p> Conclusions <p>This NHS Trust-supported high-quality facilitated research career pathway has lasting effects, increasing research knowledge and skills, informing and changing participants’ clinical practice, building confidence, increasing research-related activities undertaken and career progression. The programme’s range of opportunities across the whole pathway, the strong collaborative partnership between the NHS Trust and partner Higher Education Institute (HEI) and visible support for research are important contributors to the programme’s impact. However, challenges to pursuing a clinical academic career for NMAHP+s persist and require further attention.</p>