Background <p>With the increasing global demand for surgeons, particularly in low- and middle-income countries (LMICs), Surgery Interest Groups (SIGs) have emerged as transformative platforms within medical schools, providing mentorship and skill-building opportunities at an early stage to foster interest. The Khyber Medical College Surgery Interest Group (KMCSIG) was established in 2023 to inspire and support medical students through early clinical exposure, workshops, mentorship, and career counseling. This study evaluates KMCSIG’s impact on shaping career interests, addressing barriers, and promoting inclusivity, particularly in resource-limited settings.</p> Methods <p>A qualitative, descriptive case study approach was utilized, involving interviews with ten medical students from KMCSIG. Purposive sampling was employed, and thematic analysis identified key patterns and themes. This study adhered to COREQ guidelines and was approved by the Ethical Review Board of Khyber Medical University - Institute of Health Professions Education &amp; Research, Peshawar, Pakistan. NVivo software facilitated systematic coding and theme generation.</p> Results <p>Participants described numerous challenges faced as surgical aspirants in a resource-limited setting. Personal and professional barriers, including limited clinical exposure, cultural constraints, and a lack of mentorship, especially for female students, negatively influenced their interest in pursuing surgery as a career. Participants highlighted that KMCSIG has been transformative in addressing the gender-specific issues faced by female aspirants by introducing members to female role models and providing an inclusive environment with equal opportunities. Moreover, KMCSIG contributed to the overall surgical education in medical school through skill development, structured mentorship, and small-group clinical rotations, allowing for personalized attention and maximizing learning outcomes. Participants also reported professional growth through the leadership and research opportunities provided by KMCSIG. To further improve the group’s effectiveness, participants suggested incorporating simulation-based training, promoting research collaborations, and establishing exchange programs to broaden learning opportunities.</p> Conclusion <p>KMCSIG has emerged as a transformative platform for bridging gaps in surgical education and mentorship by challenging stereotypes and enhancing career aspirations in surgery among medical students. By addressing gender-specific issues and maximizing opportunities in a resource-limited context, KMCSIG serves as a model for establishing SIGs in LMICs. With further improvements, increased collaboration, and funding, KMCSIG has the potential to inspire a new generation of surgeons, thereby potentially changing the landscape of local and global surgical healthcare.</p>