Background and objectives <p>Midwifery education requires the integration of thought and practical knowledge and skills. Therefore, new education methods, including gamification based education, might be able to improve midwifery education. The aim of this systematic review was to evaluate the effectiveness of gamification in midwifery education.</p> Materials and methods <p>This systematic review was conducted on both observational and experimental (quasi-experimental and randomized controlled trials) published articles in PubMed, SCOPUS, and Web Of Science till March 2024. All articles in English language that evaluated gamification-based education in midwifery or nurse-midwifery education were evaluated.</p> Results <p>Of the primary 268 articles, 6 articles (three cross-sectional and three intervention studies) were eligible for review. All studies used serious game method for educating on different aspects of care. Both digital and non-digital games were found to be more effective than traditional education in the reviewed studies. Satisfaction with game based education was lower than traditional method in one study.</p> Conclusions <p>Gamification based education can be a promising method for educating midwifery and nurse-midwifery students due to their efficiency in improving students’ knowledge and skills especially in practical fields.</p>