Background <p>In the teaching of Pedodontology, the combining of online and on-site teaching is becoming more and more widely used. This study aims to evaluate its impact on students’ academic performance and satisfaction, attempting to discover potential teaching innovations.</p> Methods <p>Undergraduate students majoring in Stomatology, a five-year program of Fujian Medical University, were selected as the research subjects. The 2021 cohort, serving as the experimental group, was taught using online and on-site methods during the pandemic, while the 2018 cohort, as the control group, received traditional teaching. Final exam results and satisfaction questionnaires from both groups were compared.</p> Results <p>One hundred and twenty responses were received with a response rate of 100%(120/120). Compared with the control group, the experimental group’s theory test scores increased by an average of 0.54 points and the practical skills test scores increased by an average of 2.11 points, but there was no significant difference (<i>P</i> &gt; 0.05). The questionnaire suggested that the experimental group demonstrated significant improvements over the control group in stimulating learning enthusiasm, enhancing learning efficiency, promoting autonomous learning, problem induction, and problem-solving abilities (<i>P</i> &lt; 0.05). In terms of satisfaction, students’ satisfaction with this course has increased by 10% (<i>P</i> &lt; 0.05).</p> Conclusion <p>During the COVID-19 pandemic, the online and on-site teaching approach adopted in Pedodontology has been proved to be effective in improving student satisfaction.</p>