Background <p>This qualitative study aims to analyse the experiences, perceptions, and motivations of patients with Diabetic Peripheral Neuropathy (DPN), who received acupuncture treatments for the symptoms of DPN as part of a Randomized-Controlled Trial (RCT).</p> Methods <p>Semi-structured interviews were carried out with participants of a two-arm RCT as part of a mixed-methods study. The interviews were conducted fact-to-face or via phone using a semi-structured interview guide with questions on living with DPN, the medical care for DPN prior to the study, the acupuncture treatments and the overall trial participation.</p> Results <p>In total, 10 participants participated between January – December 2020 in this study. All but one participant had positive experiences with acupuncture and reported a reduction of DPN symptoms. They had varying experiences and needs and adopted a range of different coping mechanisms to manage their symptoms and condition prior to participating in the RCT. Many felt dissatisfied with the lack of current treatment options and insufficient medical care for DPN and wished to reduce medication. Acceptance of acupuncture was high, particularly among those wishing to reduce medication. The findings of the qualitative study are in line with the results of the RCT.</p> Conclusions <p>Results the qualitative study indicate that acupuncture could be an acceptable and perceived effective treatment option for DPN patients. Declarations.</p> Trial registration <p>RCT: ClinicalTrials.gov NCT03755960. Registered on 11 August 2018.</p>