Scholarlink

Background <p>Neochebulinic acid, a component of <i>Terminalia chebula Retz</i>, exhibits diverse biological activities. This study aimed to investigate its anti-<i>Helicobacter pylori</i> (HP) activity.</p> Methods and materials <p>Through using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and nuclear magnetic resonance (NMR) spectroscopy, neochebulinic acid was isolated and identified. Efficacy was assessed via minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays, scanning electron microscopy (SEM), and other assays.</p> Results <p>It demonstrated neochebulinic acid’s ability to inhibit HP proliferation, damage bacterial structure, and suppress Cytotoxin-associated gene A (Cag A) protein expression, with high selectivity towards HP. Neochebulinic acid also acts as an anti-adhesive agent, preventing HP adhesion to host cells.</p> Conclusion <p>These findings suggest its potential as a targeted therapeutic against HP infections, paving the way for novel anti-HP therapies.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

In vitro antibacterial activity of neochebulinic acid from aqueous extract of Terminalia chebula Retz against Helicobacter pylori

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月24日

查看全文
  • Ling Ou,
  • Haobo Chen,
  • Yajie Hao,
  • Hengrui Liu,
  • Zhixiang Zhu,
  • Qingwei Li,
  • Zhong Feng,
  • Guimin Zhang,
  • Meicun Yao

摘要

Background

Neochebulinic acid, a component of Terminalia chebula Retz, exhibits diverse biological activities. This study aimed to investigate its anti-Helicobacter pylori (HP) activity.

Methods and materials

Through using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and nuclear magnetic resonance (NMR) spectroscopy, neochebulinic acid was isolated and identified. Efficacy was assessed via minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays, scanning electron microscopy (SEM), and other assays.

Results

It demonstrated neochebulinic acid’s ability to inhibit HP proliferation, damage bacterial structure, and suppress Cytotoxin-associated gene A (Cag A) protein expression, with high selectivity towards HP. Neochebulinic acid also acts as an anti-adhesive agent, preventing HP adhesion to host cells.

Conclusion

These findings suggest its potential as a targeted therapeutic against HP infections, paving the way for novel anti-HP therapies.

Graphical abstract