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<p>Synaptic failure in specific cholinergic networks in rat brains has been implicated in amyloid β-induced neurodegeneration. <i>Teucrium polium</i> is a promising candidate for drug development against Alzheimer’s disease (AD) and similar disorders. However, the protective effect of <i>Teucrium polium</i> against amyloid β-induced impairment of short-term synaptic plasticity is still poorly understood. In this study, we used in vivo extracellular single-unit recordings to investigate the preventive efficacy of <i>Teucrium polium</i> on Aβ(25–35)-induced aberrant neuronal activity in the hippocampus and basolateral amygdala of rats, in response to high-frequency stimulation of the cholinergic nucleus basalis magnocellularis (NBM). After 12 weeks of intracerebroventricular administration of Aβ(25–35), alterations such as decreased excitatory responses and increased inhibitory synaptic activity were observed in the NBM–hippocampus and NBM–basolateral amygdala cholinergic circuits. Treatment with <i>Teucrium polium</i> improved the balance of excitatory and inhibitory responses by modulating synaptic transmission strength and restoring short-term plasticity. Acute injection of a therapeutic dose of <i>Teucrium</i> temporarily inhibited spiking activity in single NBM neurons. Open field tests revealed that amyloid-injected rats displayed anxiety and reduced exploratory drive. Treatment with <i>Teucrium polium</i> improved these behaviors, reducing anxiety and increasing exploration. <i>Teucrium polium</i> mitigated amyloid β-induced alterations in cholinergic circuits by enhancing the adaptive capacity of short-term synaptic plasticity. These findings suggest that <i>Teucrium polium</i> could serve as a preventive strategy to delay the progression of cholinergic neurodegeneration.</p>

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Teucrium Polium ameliorates amyloid β-induced brain network disorders in rats: electrophysiological and behavioral studies

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月27日

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  • Karen Simonyan,
  • Lilit Darbinyan,
  • Lilia Hambardzumyan,
  • Larisa Manukyan,
  • Vergine Chavushyan

摘要

Synaptic failure in specific cholinergic networks in rat brains has been implicated in amyloid β-induced neurodegeneration. Teucrium polium is a promising candidate for drug development against Alzheimer’s disease (AD) and similar disorders. However, the protective effect of Teucrium polium against amyloid β-induced impairment of short-term synaptic plasticity is still poorly understood. In this study, we used in vivo extracellular single-unit recordings to investigate the preventive efficacy of Teucrium polium on Aβ(25–35)-induced aberrant neuronal activity in the hippocampus and basolateral amygdala of rats, in response to high-frequency stimulation of the cholinergic nucleus basalis magnocellularis (NBM). After 12 weeks of intracerebroventricular administration of Aβ(25–35), alterations such as decreased excitatory responses and increased inhibitory synaptic activity were observed in the NBM–hippocampus and NBM–basolateral amygdala cholinergic circuits. Treatment with Teucrium polium improved the balance of excitatory and inhibitory responses by modulating synaptic transmission strength and restoring short-term plasticity. Acute injection of a therapeutic dose of Teucrium temporarily inhibited spiking activity in single NBM neurons. Open field tests revealed that amyloid-injected rats displayed anxiety and reduced exploratory drive. Treatment with Teucrium polium improved these behaviors, reducing anxiety and increasing exploration. Teucrium polium mitigated amyloid β-induced alterations in cholinergic circuits by enhancing the adaptive capacity of short-term synaptic plasticity. These findings suggest that Teucrium polium could serve as a preventive strategy to delay the progression of cholinergic neurodegeneration.