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Background and aim <p>Menopausal symptoms have marked negative impact on women’s physical and mental well-being and consumes substantial amount of health expenses. However, the relation between <i>H. pylori</i> infection and severity of menopausal symptoms is a scarcely discussed issue. The present cross-sectional study aims to explore the relation between <i>H. pylori</i> infection and severity of menopausal symptoms in diabetic women.</p> Subjects and methods <p>The study included 150 postmenopausal diabetic women and 150 non-diabetic counterparts. <i>H. pylori</i> infection was assessed using a monoclonal enzyme immunoassay–based stool antigen test. Menopausal symptoms were evaluated using the Menopause Rating Scale (MRS).</p> Results <p>The present study included consecutive 150 diabetic and 150 non-diabetic postmenopausal women. Diabetic women had significantly higher frequency of severe menopausal symptoms (31.3% versus 14.0%, <i>p</i>&lt;0.001) and significantly higher frequency of positive <i>H. pylori</i> infection (56.0% versus 40.7%, <i>p</i> = 0.011). Multivariate binary logistic regression analysis identified significant association between BMI [OR (95% CI): 1.09 (1.01–1.18), <i>p</i> = 0.022], hypertension [OR (95% CI): 3.97 (1.66–9.49), <i>p</i> = 0.002], HbA1c % [OR (95% CI): 1.18 (1.02–1.36), <i>p</i> = 0.029] and positive <i>H. pylori</i> infection [OR (95% CI): 4.09 (1.52-11.0), <i>p</i> = 0.005] and severe menopausal symptoms.</p> Conclusions <p>Postmenopausal diabetic women had higher frequency of <i>H. pylori</i> infection which may be related to more severe menopausal symptoms in this population.</p>

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Relation between Helicobacter pylori infection and menopausal symptoms in diabetic women

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月21日

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  • Nessren Mohamed Bahaa El Deen Mohamed,
  • Noura Ali Ghazy Zidan,
  • Sara Mohammed Foaud Hussein,
  • Eman Hussein Soliman Altaweel,
  • Neamat Abdelmageed Abdelmageed,
  • Fatma Saffeyeldin Mohamed,
  • Sally Abdelaziz Ahmed,
  • Marwa Abdelaziz Abo Saree Yassien,
  • Doaa Mohamed Salama Abdelmaqsoud,
  • Sabah M. Alkhawagah,
  • Shymaa M. Elattar,
  • Marwa M. Hassan,
  • Moshira Ali Ibrahim Mohamed

摘要

Background and aim

Menopausal symptoms have marked negative impact on women’s physical and mental well-being and consumes substantial amount of health expenses. However, the relation between H. pylori infection and severity of menopausal symptoms is a scarcely discussed issue. The present cross-sectional study aims to explore the relation between H. pylori infection and severity of menopausal symptoms in diabetic women.

Subjects and methods

The study included 150 postmenopausal diabetic women and 150 non-diabetic counterparts. H. pylori infection was assessed using a monoclonal enzyme immunoassay–based stool antigen test. Menopausal symptoms were evaluated using the Menopause Rating Scale (MRS).

Results

The present study included consecutive 150 diabetic and 150 non-diabetic postmenopausal women. Diabetic women had significantly higher frequency of severe menopausal symptoms (31.3% versus 14.0%, p<0.001) and significantly higher frequency of positive H. pylori infection (56.0% versus 40.7%, p = 0.011). Multivariate binary logistic regression analysis identified significant association between BMI [OR (95% CI): 1.09 (1.01–1.18), p = 0.022], hypertension [OR (95% CI): 3.97 (1.66–9.49), p = 0.002], HbA1c % [OR (95% CI): 1.18 (1.02–1.36), p = 0.029] and positive H. pylori infection [OR (95% CI): 4.09 (1.52-11.0), p = 0.005] and severe menopausal symptoms.

Conclusions

Postmenopausal diabetic women had higher frequency of H. pylori infection which may be related to more severe menopausal symptoms in this population.