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Background <p>This study investigated the latent profiles of reproductive concerns among women of childbearing age with systemic lupus erythematosus (SLE) and analyzed the differences in the characteristics across these profiles.</p> Methods <p>A questionnaire was administered to 332 female patients of childbearing age with SLE at four tertiary-grade general hospitals in Mianyang City, China. We used a general information questionnaire, the Reproductive Concerns After Cancer Scale (RCAC), the Medical Coping Modes Questionnaire (MCMQ), and the Social Support Rating Scale (SSRS). A latent profile analysis (LPA) and multiple logistic regression models were employed to investigate the characteristics of the latent profiles and the factors that influence reproductive concerns.</p> Results <p>The total score for the reproductive concerns among women with SLE of childbearing age was moderate (58.45 ± 13.51). Four latent profiles were identified: low reproductive concern–high infertility acceptance (12.66%), moderate reproductive concern–concern about personal health (18.95%), moderate reproductive concern–concern about the child’s health (45.64%), and high reproductive concern–balance (22.75%). The model fit indices that support the four latent profiles included high entropy (0.92) and a significant result of the Lo–Mendell–Rubin (LMR) adjusted likelihood ratio test (<i>P</i> &lt; 0.001). The factors that influence the reproductive concern categories included age, marital status, annual income, method of medical payment, number of children, fertility intention, a history of adverse pregnancy outcomes (APOs), disease activity, social support, and medical coping strategies (<i>P</i> &lt; 0.05).</p> Conclusions <p>The reproductive concerns observed among women of childbearing age with SLE exhibited significant heterogeneity. In the field of clinical nursing, personalized intervention measures should be developed based on distinct categorical characteristics and influencing factors to reduce reproductive concerns among members of this patient population.</p>

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Latent profile analysis of reproductive concern among women of childbearing age with systemic lupus erythematosus in China: a cross-sectional study

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  • 发表日期：

    2026年2月17日

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  • Jia Pu,
  • Lan Huang,
  • Yuemei Li,
  • Qianmei Zhong

摘要

Background

This study investigated the latent profiles of reproductive concerns among women of childbearing age with systemic lupus erythematosus (SLE) and analyzed the differences in the characteristics across these profiles.

Methods

A questionnaire was administered to 332 female patients of childbearing age with SLE at four tertiary-grade general hospitals in Mianyang City, China. We used a general information questionnaire, the Reproductive Concerns After Cancer Scale (RCAC), the Medical Coping Modes Questionnaire (MCMQ), and the Social Support Rating Scale (SSRS). A latent profile analysis (LPA) and multiple logistic regression models were employed to investigate the characteristics of the latent profiles and the factors that influence reproductive concerns.

Results

The total score for the reproductive concerns among women with SLE of childbearing age was moderate (58.45 ± 13.51). Four latent profiles were identified: low reproductive concern–high infertility acceptance (12.66%), moderate reproductive concern–concern about personal health (18.95%), moderate reproductive concern–concern about the child’s health (45.64%), and high reproductive concern–balance (22.75%). The model fit indices that support the four latent profiles included high entropy (0.92) and a significant result of the Lo–Mendell–Rubin (LMR) adjusted likelihood ratio test (P < 0.001). The factors that influence the reproductive concern categories included age, marital status, annual income, method of medical payment, number of children, fertility intention, a history of adverse pregnancy outcomes (APOs), disease activity, social support, and medical coping strategies (P < 0.05).

Conclusions

The reproductive concerns observed among women of childbearing age with SLE exhibited significant heterogeneity. In the field of clinical nursing, personalized intervention measures should be developed based on distinct categorical characteristics and influencing factors to reduce reproductive concerns among members of this patient population.