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Background <p>Endometriosis is a prevalent chronic condition that causes persistent pelvic pain, significantly impairing quality of life and contributing to psychological distress. This study aimed to assess the prevalence of clinically significant symptoms of depression and anxiety among women with endometriosis and to identify factors associated with these mental health outcomes.</p> Methods <p>This cross-sectional study was conducted between 2023 and 2024 at Shahid Kamali Hospital, Karaj, Iran. Women with a confirmed diagnosis of endometriosis by a gynecologist were recruited using convenience sampling. Participants completed the Hospital Anxiety and Depression Scale (HADS), a validated self-report screening tool, and clinical data were extracted from medical records. Univariate and multivariate logistic regression analyses were performed to identify demographic and clinical factors associated with clinically significant symptoms of depression and anxiety.</p> Results <p>A total of 112 women participated (mean age: 31.6 ± 4.9 years; mean BMI: 26.3 ± 3.7&#xa0;kg/m²). The prevalence of clinically significant symptoms of depression and anxiety was 59.8% (95% CI: 50.4–68.6) and 54.5% (95% CI: 45.1–63.6), respectively. Univariate analyses showed that longer disease duration and higher pain intensity were significantly associated with depression, while education level was associated with anxiety. No significant association was found between endometriosis severity and either outcome. In the multivariate model, age, disease duration, and pain intensity remained significant correlates of depression, while education level and age were associated with anxiety.</p> Conclusions <p>Clinically significant symptoms of depression and anxiety were highly prevalent among women with endometriosis. Disease duration and pain intensity were the main factors associated with depressive symptoms, while education level was linked to anxiety. These findings emphasize the need for integrated physical and psychological care for women with endometriosis, particularly those experiencing prolonged disease and chronic pain.</p>

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Prevalence and associated factors of clinically significant symptoms of depression and anxiety among women with endometriosis in Iran

  • 期刊论文

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  • 发表日期：

    2026年2月3日

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  • Sarvenaz Emadi,
  • Negin Fallahi-Khoshknab,
  • Samira Abdollahi,
  • Negar Emadi

摘要

Background

Endometriosis is a prevalent chronic condition that causes persistent pelvic pain, significantly impairing quality of life and contributing to psychological distress. This study aimed to assess the prevalence of clinically significant symptoms of depression and anxiety among women with endometriosis and to identify factors associated with these mental health outcomes.

Methods

This cross-sectional study was conducted between 2023 and 2024 at Shahid Kamali Hospital, Karaj, Iran. Women with a confirmed diagnosis of endometriosis by a gynecologist were recruited using convenience sampling. Participants completed the Hospital Anxiety and Depression Scale (HADS), a validated self-report screening tool, and clinical data were extracted from medical records. Univariate and multivariate logistic regression analyses were performed to identify demographic and clinical factors associated with clinically significant symptoms of depression and anxiety.

Results

A total of 112 women participated (mean age: 31.6 ± 4.9 years; mean BMI: 26.3 ± 3.7 kg/m²). The prevalence of clinically significant symptoms of depression and anxiety was 59.8% (95% CI: 50.4–68.6) and 54.5% (95% CI: 45.1–63.6), respectively. Univariate analyses showed that longer disease duration and higher pain intensity were significantly associated with depression, while education level was associated with anxiety. No significant association was found between endometriosis severity and either outcome. In the multivariate model, age, disease duration, and pain intensity remained significant correlates of depression, while education level and age were associated with anxiety.

Conclusions

Clinically significant symptoms of depression and anxiety were highly prevalent among women with endometriosis. Disease duration and pain intensity were the main factors associated with depressive symptoms, while education level was linked to anxiety. These findings emphasize the need for integrated physical and psychological care for women with endometriosis, particularly those experiencing prolonged disease and chronic pain.