Scholarlink

Background <p>Fibroadenomas are common benign breast tumors, but recurrent bilateral giant fibroadenomas are rare. Recent studies suggest genetic factors, such as <i>PIK3CA</i> mutations, may influence tumor behavior.</p> Case presentation <p>A 23-year-old woman with prior multiple fibroadenoma excisions presented with progressively enlarging bilateral breast masses and marked deformity. Imaging revealed multiple well-circumscribed lesions, the largest measuring 7.5 cm. Serum prolactin was elevated; estradiol and progesterone were normal. She underwent bilateral excision with reduction mammoplasty and nipple–areolar reconstruction. Histology confirmed fibroadenomas with epithelial hyperplasia; immunohistochemistry showed diffuse estrogen receptor positivity (&gt;90% of cells) and a Ki-67 index of 5–10%. Next-generation sequencing detected a somatic <i>PIK3CA</i>c.317G&gt;T (p.G106V) mutation.</p> Conclusion <p>Integration of histological, hormonal, and molecular findings can guide individualized management of recurrent fibroadenomas. Large-scale studies are required to assess the prognostic significance of <i>PIK3CA</i> mutations in benign breast tumors.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Recurrent bilateral giant breast fibroadenomas with a somatic PIK3CA p.G106V mutation: case report and review of current evidence

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月21日

查看全文
  • Yuemei Zhang,
  • Qixing Tan,
  • Yugui Xiao,
  • Wenhao Wang,
  • Shengkai Huang,
  • Qinguo Mo,
  • Wenhai Zhang,
  • Wei Wei

摘要

Background

Fibroadenomas are common benign breast tumors, but recurrent bilateral giant fibroadenomas are rare. Recent studies suggest genetic factors, such as PIK3CA mutations, may influence tumor behavior.

Case presentation

A 23-year-old woman with prior multiple fibroadenoma excisions presented with progressively enlarging bilateral breast masses and marked deformity. Imaging revealed multiple well-circumscribed lesions, the largest measuring 7.5 cm. Serum prolactin was elevated; estradiol and progesterone were normal. She underwent bilateral excision with reduction mammoplasty and nipple–areolar reconstruction. Histology confirmed fibroadenomas with epithelial hyperplasia; immunohistochemistry showed diffuse estrogen receptor positivity (>90% of cells) and a Ki-67 index of 5–10%. Next-generation sequencing detected a somatic PIK3CAc.317G>T (p.G106V) mutation.

Conclusion

Integration of histological, hormonal, and molecular findings can guide individualized management of recurrent fibroadenomas. Large-scale studies are required to assess the prognostic significance of PIK3CA mutations in benign breast tumors.