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Introduction <p>Primary dysmenorrhea is a common condition characterized by painful menstrual cramps. Vitamin D and E are suggested to have potential benefits in managing dysmenorrhea. This study aimed to investigate the effects of vitamin D and E supplements combination on pain intensity and premenstrual symptoms in individuals with primary dysmenorrhea.</p> Methods <p>A double blinded randomized controlled trial was conducted with 106 participants diagnosed with primary dysmenorrhea. The participants were randomly assigned to either the intervention group (received vitamin D and E supplements) or the control group (received placebo). Pain intensity and premenstrual symptoms were assessed at baseline and after four months of supplementation.</p> Results <p>The intervention group exhibited a significant reduction in pain intensity (NPRS: from 7.85 ± 1.15 to 3.75 ± 1.40; mean difference − 4.10, 95% CI: -4.61 to -3.58, <i>p</i> &lt; 0.001) compared to controls (7.68 ± 1.20 to 6.02 ± 1.70). Premenstrual symptoms significantly improved (PMS score: 32.42 ± 4.67 to 9.02 ± 8.84, Δ=-23.40, 95% CI: -26.51 to -21.02, <i>p</i> &lt; 0.001). Baseline vitamin D inversely correlated with pain (<i>r</i>=-0.768, <i>p</i> = 0.001).</p> Conclusion <p>Combined vitamin D and E supplementation significantly reduces pain and PMS in vitamin D-deficient women. Healthcare providers may consider this regimen for dysmenorrhea management, pending further optimization studies.</p> Trial registration <p>In IRCT.ir with number IRCT20220720055506N1 at 2023-02-01.</p>

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Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月29日

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  • Maryam Sadat Hosseini,
  • Maryam Talayeh,
  • Alireza Haghbin Toutounchi,
  • Afsaneh Hosseini,
  • Nesa Moradi,
  • Saeideh Iranshahi,
  • Fatemeh Abdollahi Aliabadi

摘要

Introduction

Primary dysmenorrhea is a common condition characterized by painful menstrual cramps. Vitamin D and E are suggested to have potential benefits in managing dysmenorrhea. This study aimed to investigate the effects of vitamin D and E supplements combination on pain intensity and premenstrual symptoms in individuals with primary dysmenorrhea.

Methods

A double blinded randomized controlled trial was conducted with 106 participants diagnosed with primary dysmenorrhea. The participants were randomly assigned to either the intervention group (received vitamin D and E supplements) or the control group (received placebo). Pain intensity and premenstrual symptoms were assessed at baseline and after four months of supplementation.

Results

The intervention group exhibited a significant reduction in pain intensity (NPRS: from 7.85 ± 1.15 to 3.75 ± 1.40; mean difference − 4.10, 95% CI: -4.61 to -3.58, p < 0.001) compared to controls (7.68 ± 1.20 to 6.02 ± 1.70). Premenstrual symptoms significantly improved (PMS score: 32.42 ± 4.67 to 9.02 ± 8.84, Δ=-23.40, 95% CI: -26.51 to -21.02, p < 0.001). Baseline vitamin D inversely correlated with pain (r=-0.768, p = 0.001).

Conclusion

Combined vitamin D and E supplementation significantly reduces pain and PMS in vitamin D-deficient women. Healthcare providers may consider this regimen for dysmenorrhea management, pending further optimization studies.

Trial registration

In IRCT.ir with number IRCT20220720055506N1 at 2023-02-01.