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Objective <p>This study aimed to investigate the effects of cyst volume and bilaterality on serum Anti-Müllerian Hormone (AMH) and CA-125 levels in patients with benign ovarian cysts.</p> Methods <p>We retrospectively analyzed 139 patients who underwent cystectomy for benign ovarian cysts. Serum AMH and CA-125 levels were measured preoperatively and at the second post-operative month.</p> Results <p>The mean preoperative AMH level was 3.96 ± 3.48 ng/mL, which significantly decreased to 3.59 ± 3.92 ng/mL postoperatively (<i>p</i> = 0.026), reflecting an average decline of 9.3%. CA-125 levels significantly decreased from 53.1 ± 157.2 to 21.0 ± 18.4 U/mL (<i>p</i> = 0.002). Patients with bilateral cysts had lower AMH levels at the second month (1.67 ± 0.6 vs. 3.80 ± 4.1 ng/mL; <i>p</i> = 0.003) despite similar baseline values.</p> Conclusion <p>Bilaterality and cyst volume may negatively affect ovarian reserve postoperatively. The decline in AMH levels, particularly following bilateral ovarian cystectomy, has a significant impact on the ovarian reserve and may have implications for future fertility. Early fertility counselling and ovarian preservation strategies should be considered during surgical planning.</p>

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Effects of benign ovarian cyst volume and laterality on AMH and CA-125 levels

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月4日

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  • Aykut Kından,
  • Aziz Kından,
  • Ahmet Kurt,
  • Volkan Özgür Akbulut,
  • Berna Dilbaz

摘要

Objective

This study aimed to investigate the effects of cyst volume and bilaterality on serum Anti-Müllerian Hormone (AMH) and CA-125 levels in patients with benign ovarian cysts.

Methods

We retrospectively analyzed 139 patients who underwent cystectomy for benign ovarian cysts. Serum AMH and CA-125 levels were measured preoperatively and at the second post-operative month.

Results

The mean preoperative AMH level was 3.96 ± 3.48 ng/mL, which significantly decreased to 3.59 ± 3.92 ng/mL postoperatively (p = 0.026), reflecting an average decline of 9.3%. CA-125 levels significantly decreased from 53.1 ± 157.2 to 21.0 ± 18.4 U/mL (p = 0.002). Patients with bilateral cysts had lower AMH levels at the second month (1.67 ± 0.6 vs. 3.80 ± 4.1 ng/mL; p = 0.003) despite similar baseline values.

Conclusion

Bilaterality and cyst volume may negatively affect ovarian reserve postoperatively. The decline in AMH levels, particularly following bilateral ovarian cystectomy, has a significant impact on the ovarian reserve and may have implications for future fertility. Early fertility counselling and ovarian preservation strategies should be considered during surgical planning.