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Background <p>Oral microbiome dysbiosis may contribute to autoimmune disease development, but epidemiological evidence linking oral health and autoimmune disease risk is limited.</p> Objectives <p>To evaluate the association between self-reported oral health issues by questionnaire—defined as the presence of painful or bleeding gums, mouth ulcers, toothache, dentures, or loose teeth—and the risk of incident autoimmune diseases in the UK Biobank cohort.</p> Materials and methods <p>Individuals reporting any oral health issues (painful/bleeding gums, mouth ulcers, toothache, dentures, and loose teeth) were classified as any self-reported oral health issues; others as no self-reported oral health issues. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for any autoimmune diseases and 39 types of autoimmune diseases using Cox regression models with Bonferroni correction. We investigated associations of the type and number of self-reported oral health issues with autoimmune diseases.</p> Results <p>Among 451,404 participants (mean age: 56.4 years, 54.2% female), any self-reported oral health issues (<i>N</i> = 177,198; 39.3%) were associated with an increased risk of any autoimmune diseases (HR 1.11, 95% CI 1.09–1.14). Painful gums showed the strongest association (HR 1.39, 95% CI 1.31–1.47), followed by mouth ulcers (1.23, 1.18–1.27) and toothache (1.21, 1.15–1.27). Risk increased with the number of self-reported oral health issues (per 1–issue increase: HR 1.09, 95% CI 1.08–1.11, P-trend &lt; 0.001). For specific autoimmune disease, primary biliary cholangitis (HR 1.65, 95% CI 1.24–2.19), rheumatism (1.48, 1.23–1.77), lichen planus (1.35, 1.15–1.57), Sjögren’s disease (1.30, 1.11–1.52), pernicious anemia (1.28, 1.12–1.46), rheumatoid arthritis (1.18, 1.12–1.26), and psoriasis (1.16, 1.07–1.26) were identified.</p> Conclusions <p>Self-reported oral health issues were associated with an increased risk of incident autoimmune diseases, suggesting that oral health indicators may serve as clinically relevant markers of autoimmune disease risk.</p>

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Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Dongwon Yoon,
  • Barbanente Ottavio,
  • Choa Yun,
  • Sun-Young Jung,
  • May A. Beydoun,
  • Lenore J. Launer,
  • Minkyo Song

摘要

Background

Oral microbiome dysbiosis may contribute to autoimmune disease development, but epidemiological evidence linking oral health and autoimmune disease risk is limited.

Objectives

To evaluate the association between self-reported oral health issues by questionnaire—defined as the presence of painful or bleeding gums, mouth ulcers, toothache, dentures, or loose teeth—and the risk of incident autoimmune diseases in the UK Biobank cohort.

Materials and methods

Individuals reporting any oral health issues (painful/bleeding gums, mouth ulcers, toothache, dentures, and loose teeth) were classified as any self-reported oral health issues; others as no self-reported oral health issues. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for any autoimmune diseases and 39 types of autoimmune diseases using Cox regression models with Bonferroni correction. We investigated associations of the type and number of self-reported oral health issues with autoimmune diseases.

Results

Among 451,404 participants (mean age: 56.4 years, 54.2% female), any self-reported oral health issues (N = 177,198; 39.3%) were associated with an increased risk of any autoimmune diseases (HR 1.11, 95% CI 1.09–1.14). Painful gums showed the strongest association (HR 1.39, 95% CI 1.31–1.47), followed by mouth ulcers (1.23, 1.18–1.27) and toothache (1.21, 1.15–1.27). Risk increased with the number of self-reported oral health issues (per 1–issue increase: HR 1.09, 95% CI 1.08–1.11, P-trend < 0.001). For specific autoimmune disease, primary biliary cholangitis (HR 1.65, 95% CI 1.24–2.19), rheumatism (1.48, 1.23–1.77), lichen planus (1.35, 1.15–1.57), Sjögren’s disease (1.30, 1.11–1.52), pernicious anemia (1.28, 1.12–1.46), rheumatoid arthritis (1.18, 1.12–1.26), and psoriasis (1.16, 1.07–1.26) were identified.

Conclusions

Self-reported oral health issues were associated with an increased risk of incident autoimmune diseases, suggesting that oral health indicators may serve as clinically relevant markers of autoimmune disease risk.