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Background <p>Food allergy is a common immune-mediated condition in children and is increasingly recognized to affect the oral cavity. Oral manifestations may represent early signs of allergic sensitization and can influence oral health, nutrition, and quality of life. This systematic review aimed to synthesize the available evidence on oral manifestations associated with food allergies in pediatric populations.</p> Methods <p>A systematic literature search was conducted in PubMed Medline, Scopus, Web of Science, and the Cochrane Library for studies published up to December 2025. Eligibility criteria included observational and clinical studies published in English that reported oral or dental manifestations in children and adolescents aged 0–18 years with diagnosed IgE-mediated or non-IgE-mediated food allergy. Study selection, data extraction, and risk of bias assessment were performed independently by two reviewers in accordance with PRISMA 2020 guidelines. The quality of included studies was assessed using the Newcastle-Ottawa Scale.</p> Results <p>Twelve pediatric studies met the inclusion criteria. The most frequently reported oral manifestations were itching and tingling of the lips, tongue, palate, and oral mucosa following ingestion of specific foods, particularly fruits and nuts. Mild labial and oral mucosal swelling were also commonly described. These symptoms were consistent with oral allergy syndrome and were most frequently observed in school-aged children with pollen sensitization. Oral manifestations occurred rapidly after food exposure and were reproducible across different populations and geographic regions.</p> Conclusion <p>Oral manifestations are common features of pediatric food allergy and frequently represent localized IgE-mediated reactions. Recognition of these symptoms is important for early identification of food allergy and appropriate referral. Increased awareness among pediatric dentists may contribute to improved detection and multidisciplinary management of affected children.</p>

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From systemic immune dysregulation to oral disease: evidence linking food allergies and oral manifestations- a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Pratyasha Sharma,
  • Srikala Bhandary,
  • Sayan Das,
  • Syed Taha

摘要

Background

Food allergy is a common immune-mediated condition in children and is increasingly recognized to affect the oral cavity. Oral manifestations may represent early signs of allergic sensitization and can influence oral health, nutrition, and quality of life. This systematic review aimed to synthesize the available evidence on oral manifestations associated with food allergies in pediatric populations.

Methods

A systematic literature search was conducted in PubMed Medline, Scopus, Web of Science, and the Cochrane Library for studies published up to December 2025. Eligibility criteria included observational and clinical studies published in English that reported oral or dental manifestations in children and adolescents aged 0–18 years with diagnosed IgE-mediated or non-IgE-mediated food allergy. Study selection, data extraction, and risk of bias assessment were performed independently by two reviewers in accordance with PRISMA 2020 guidelines. The quality of included studies was assessed using the Newcastle-Ottawa Scale.

Results

Twelve pediatric studies met the inclusion criteria. The most frequently reported oral manifestations were itching and tingling of the lips, tongue, palate, and oral mucosa following ingestion of specific foods, particularly fruits and nuts. Mild labial and oral mucosal swelling were also commonly described. These symptoms were consistent with oral allergy syndrome and were most frequently observed in school-aged children with pollen sensitization. Oral manifestations occurred rapidly after food exposure and were reproducible across different populations and geographic regions.

Conclusion

Oral manifestations are common features of pediatric food allergy and frequently represent localized IgE-mediated reactions. Recognition of these symptoms is important for early identification of food allergy and appropriate referral. Increased awareness among pediatric dentists may contribute to improved detection and multidisciplinary management of affected children.