Background <p>Cancer significantly impairs oral health and quality of life of patients, particularly by physical discomfort, which in turn disrupts one’s social and psychological functioning. This study aimed to assess the psychometric properties of the Oral Impacts on Daily Performances (OIDP) amongst Head &amp; Neck Cancer patients and evaluates the relationship between oral health quality of life and patients’ socio-demographic factors.</p> Methods <p>This cross-sectional study was conducted with 86 head and neck cancer patients aged 18 to 68 years. A validated questionnaire, the OIDP scale evaluated the impact of compromised oral health on the day-to-day activities of an individual. Cronbach’s alpha determined the reliability of the scale. Psychometric evaluation included Factor analysis, Pearson’s correlation and regression analysis to explore the relationships between OIDP domains and clinical and demographic variables.</p> Results <p>Most participants were male (70.9%). The OIDP demonstrated good internal consistency (Cronbach’s alpha = 0.877). Factor analysis identified four distinct dimensions of oral health-related quality of life - functional/physical impact and social/psychological and sensory impact. Inter-domain correlations revealed that impairments in one aspect of daily life (e.g., eating or sleeping) were strongly linked to difficulties in emotional regulation and social engagement, emphasizing the interconnected nature of these domains.</p> Conclusions <p>This study underscores that head and neck cancer severely affects the physical, psychological and social aspects of one's daily life. Strong correlations between eating issues, emotional well-being, and social interactions were found among the cancer patients. Hence the need for holistic oral care approaches particularly for vulnerable populations is inevitable.</p>