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Introduction <p>Low-intensity pulsed ultrasound (LIPUS) has been proposed as a non-invasive adjunct to accelerate orthodontic tooth movement (OTM) and reduce treatment-related pain, but findings remain inconsistent. This systematic review and meta-analysis aimed to evaluate its clinical effectiveness.</p> Method <p>This systematic review and meta-analysis followed PRISMA 2020. Comprehensive literature searches were conducted in PubMed, Embase, Scopus, Cochrane Library, and Web of Science, covering all records available up to May 25, 2025. Eligible human studies were assessed for risk of bias and data were systematically extracted. All included studies were synthesized qualitatively, while pain outcomes at 24&#xa0;h from four studies were pooled using a random-effects model.</p> Results <p>Eleven studies met inclusion: 4 evaluated OTM only, 4 pain only, and 3 both—yielding 7 studies per outcome domain. The meta-analysis for four studies showed no significant difference in pain at 24&#xa0;h between LIPUS and controls (MD = − 0.76; 95% CI − 2.86 to 1.33; <i>p</i> = 0.48; I<sup>2</sup> = 93%). However, individual trials reported variable short-term analgesic effects. Evidence for OTM acceleration was mixed, ranging from substantial acceleration to negligible effect. Considerable heterogeneity in study design, intervention protocols and outcome definitions limited comparability.</p> Conclusion <p>LIPUS may represent a promising non-invasive adjunct in orthodontics, yet current evidence remains insufficient to support its routine clinical use for either pain management or tooth movement acceleration. Further high-quality randomized controlled trials with standardized application protocols and consistent outcome measures are needed to clarify its effectiveness.</p> Systematic review registration <p>PROSPERO CRD 420,251,069,418.</p>

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Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and pain perception in human studies: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月16日

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  • Arsalan Shahri,
  • Hanieh Kazemi,
  • Erfan Bardideh,
  • Zahra Bahadorani

摘要

Introduction

Low-intensity pulsed ultrasound (LIPUS) has been proposed as a non-invasive adjunct to accelerate orthodontic tooth movement (OTM) and reduce treatment-related pain, but findings remain inconsistent. This systematic review and meta-analysis aimed to evaluate its clinical effectiveness.

Method

This systematic review and meta-analysis followed PRISMA 2020. Comprehensive literature searches were conducted in PubMed, Embase, Scopus, Cochrane Library, and Web of Science, covering all records available up to May 25, 2025. Eligible human studies were assessed for risk of bias and data were systematically extracted. All included studies were synthesized qualitatively, while pain outcomes at 24 h from four studies were pooled using a random-effects model.

Results

Eleven studies met inclusion: 4 evaluated OTM only, 4 pain only, and 3 both—yielding 7 studies per outcome domain. The meta-analysis for four studies showed no significant difference in pain at 24 h between LIPUS and controls (MD = − 0.76; 95% CI − 2.86 to 1.33; p = 0.48; I2 = 93%). However, individual trials reported variable short-term analgesic effects. Evidence for OTM acceleration was mixed, ranging from substantial acceleration to negligible effect. Considerable heterogeneity in study design, intervention protocols and outcome definitions limited comparability.

Conclusion

LIPUS may represent a promising non-invasive adjunct in orthodontics, yet current evidence remains insufficient to support its routine clinical use for either pain management or tooth movement acceleration. Further high-quality randomized controlled trials with standardized application protocols and consistent outcome measures are needed to clarify its effectiveness.

Systematic review registration

PROSPERO CRD 420,251,069,418.