Scholarlink

Objectives <p>Histological and histomorphometric evaluation of the efficacy of custom-made three-dimensional (3D) printed poly-lactic acid (PLA)/ polyethylene glycol (PEG) scaffolds in horizontal soft tissue augmentation compared to connective tissue grafts (CTG) in Mongrel dogs.</p> Materials and methods <p>Horizontal ridge defects were created after tooth extraction in 12 dogs, then randomly allocated to one of the 3 study groups. 1 month after the first surgery, defects were augmented using custom-made 3D printed PLA/PEG scaffolds, or CTG or were left empty. 6 dogs were sacrificed after 1 month post-operatively, and 6 dogs after 3 months. Samples were collected for histologic evaluation.</p> Results <p>PLA/PEG and CTG groups successfully augmented soft tissue thickness. Histomorphometrically, fibroblast count (FC) was significantly higher in PLA/PEG group at both time points in comparison to CTG (<i>p</i> = 0.002 and 0.007) and control groups (<i>p</i> = 0.001 and 0.016). Percentage of collagen surface area (%CSA) was significantly higher in PLA/PEG group compared to other groups at 1 month (<i>p</i> = 0.021 and 0.001), however, it was higher in CTG group at 3 months (<i>p</i> = 0.024 and 0.003).</p> Conclusions <p>3D printed custom-made PLA/PEG scaffolds are an easy, effective, and safe method for soft tissue volume augmentation.</p> Clinical relevance <p>The use of 3D printed scaffolds with properly designed internal structure guides the type of tissues regenerated and eliminates the need for CTG with its higher morbidity and complications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluation of custom-made 3D printed polylactic acid/polyethylene glycol scaffolds in soft tissue augmentation: an experimental study in a canine model

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月27日

查看全文
  • Eman El-Mahalawy,
  • Fatma Ramzy Kamel,
  • Maha R. Taalab,
  • Moustafa Aboushleib,
  • Azza Saleh Koura,
  • Wessam M. Amin

摘要

Objectives

Histological and histomorphometric evaluation of the efficacy of custom-made three-dimensional (3D) printed poly-lactic acid (PLA)/ polyethylene glycol (PEG) scaffolds in horizontal soft tissue augmentation compared to connective tissue grafts (CTG) in Mongrel dogs.

Materials and methods

Horizontal ridge defects were created after tooth extraction in 12 dogs, then randomly allocated to one of the 3 study groups. 1 month after the first surgery, defects were augmented using custom-made 3D printed PLA/PEG scaffolds, or CTG or were left empty. 6 dogs were sacrificed after 1 month post-operatively, and 6 dogs after 3 months. Samples were collected for histologic evaluation.

Results

PLA/PEG and CTG groups successfully augmented soft tissue thickness. Histomorphometrically, fibroblast count (FC) was significantly higher in PLA/PEG group at both time points in comparison to CTG (p = 0.002 and 0.007) and control groups (p = 0.001 and 0.016). Percentage of collagen surface area (%CSA) was significantly higher in PLA/PEG group compared to other groups at 1 month (p = 0.021 and 0.001), however, it was higher in CTG group at 3 months (p = 0.024 and 0.003).

Conclusions

3D printed custom-made PLA/PEG scaffolds are an easy, effective, and safe method for soft tissue volume augmentation.

Clinical relevance

The use of 3D printed scaffolds with properly designed internal structure guides the type of tissues regenerated and eliminates the need for CTG with its higher morbidity and complications.