Background <p>Pediatric dentists can play a crucial role in detecting, referring, counselling, and treating patients with obstructive sleep apnea (OSA). Understanding their knowledge and attitudes towards OSA is crucial for effective healthcare delivery.</p> Objective <p>This study aimed to assess the knowledge, attitude, and practice of pediatric dentists in Egypt toward obstructive sleep apnea in children.</p> Methods <p>This cross-sectional study used a web-based structured questionnaire generated via Google Forms based on a previously validated questionnaire. The link for the questionnaire was circulated to participants through emails and professional group forums. The questionnaire comprised an introductory paragraph and four sections: demographic, knowledge, attitude, and practice for data collection.</p> Results <p>A total of 362 pediatric dentists participated in this online survey. Adequate knowledge was detected in 310 (85.64%) pediatric dentists, and 343 (94.75%) demonstrated a positive attitude toward OSA. In contrast, inadequate practices were observed in 274 (75.69%) pediatric dentists. Concerning the correlation between the knowledge, attitude, and practice and demographic data, a weak negative correlation with statistical significance (<i>p</i>-value = 0.047186) was detected between practice and age. A weak positive correlation was also detected between knowledge and years of experience, with a statistical significance (<i>p</i>-value = 0.011848).</p> Conclusions <p>Pediatric dentists in Egypt seem to have adequate knowledge and a positive attitude toward different domains of pediatric OSA, but their practice was inadequate. Participants’ knowledge showed a weak favourable correlation with years of experience; meanwhile, their practice has an adverse weak relationship with age.</p> Trial registration <p>The current study was registered on May 6, 2025, with the identifier number NCT06970873 on clinicaltrials.gov.</p>