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Objective <p>This study aimed to evaluate the osteoinductive potential of a composite material consisting of Naringin, bone marrow stromal cells (BMSCs), and calcium phosphate cement (CPC) for alveolar ridge preservation and tooth extraction wound healing in Beagle dogs.</p> Materials and methods <p>Six Beagle dogs underwent bilateral extraction of the mandibular first through fourth premolars. The extraction sites were treated with one of the following: Naringin/BMSCs + CPC, BMSCs + CPC, blank control, and Bio-Oss. Samples were collected at 4, 8, and 12 weeks, with two dogs per time point. Evaluations included gross examination, cone-beam computed tomography (CBCT), micro-computed tomography (Micro-CT), and histological analysis.</p> Results <p>CBCT revealed minimal alveolar ridge changes in the Naringin/BMSCs + CPC and Bio-Oss groups, while significant resorption was observed in the control group. Micro-CT showed superior bone volume fraction, trabecular number, and bone mineral density in the experimental groups compared to the control group. Histology confirmed higher new bone formation in the Naringin/BMSCs + CPC and Bio-Oss groups.</p> Conclusion <p>The Naringin/BMSCs/CPC composite showed significant osteogenic potential, promoting extraction site healing and enhancing alveolar ridge regeneration. This composite may serve as a viable option for clinical alveolar ridge preservation.</p> Clinical relevance <p>The Naringin/BMSCs/CPC composite may provide a promising approach for preserving alveolar ridges and enhancing bone regeneration in clinical dental practices, potentially improving outcomes for patients undergoing tooth extractions.</p>

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Evaluation of the osteogenic effect of Naringin-enhanced bmscs/cpc composite for alveolar ridge preservation and tooth extraction wound healing in beagle dogs

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月19日

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  • Xin Yang,
  • Peng Sun,
  • Deming Yu,
  • Xinjie Liang,
  • Xuebin Zhang

摘要

Objective

This study aimed to evaluate the osteoinductive potential of a composite material consisting of Naringin, bone marrow stromal cells (BMSCs), and calcium phosphate cement (CPC) for alveolar ridge preservation and tooth extraction wound healing in Beagle dogs.

Materials and methods

Six Beagle dogs underwent bilateral extraction of the mandibular first through fourth premolars. The extraction sites were treated with one of the following: Naringin/BMSCs + CPC, BMSCs + CPC, blank control, and Bio-Oss. Samples were collected at 4, 8, and 12 weeks, with two dogs per time point. Evaluations included gross examination, cone-beam computed tomography (CBCT), micro-computed tomography (Micro-CT), and histological analysis.

Results

CBCT revealed minimal alveolar ridge changes in the Naringin/BMSCs + CPC and Bio-Oss groups, while significant resorption was observed in the control group. Micro-CT showed superior bone volume fraction, trabecular number, and bone mineral density in the experimental groups compared to the control group. Histology confirmed higher new bone formation in the Naringin/BMSCs + CPC and Bio-Oss groups.

Conclusion

The Naringin/BMSCs/CPC composite showed significant osteogenic potential, promoting extraction site healing and enhancing alveolar ridge regeneration. This composite may serve as a viable option for clinical alveolar ridge preservation.

Clinical relevance

The Naringin/BMSCs/CPC composite may provide a promising approach for preserving alveolar ridges and enhancing bone regeneration in clinical dental practices, potentially improving outcomes for patients undergoing tooth extractions.