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<p>The effectiveness of Passive Ultrasonic Irrigation(PUI) and Sonically Activated Irrigation(SAI) techniques was investigated in apical periodontitis(AP) patients based on changes in prostaglandin E2(PGE2), nitric oxide(NO), and interleukin-6(IL-6) levels. Sixty-six AP patients and thirty healthy controls were enrolled. Preoperative gingival crevicular fluid(preGCF) PGE2, NO and IL-6 levels were measured before treatment. After chemo-mechanical preparation, teeth were assigned into two groups according to final irrigation protocol[PUI(n:33) and SAI(n:33)]. The same markers were again measured 1 week after treatment(postGCF) and also 1st order most commonly seen bacteria(FMCB) typing was performed on microbial samples of the patients. PostGCF-PGE2 levels of the PUI group were lower than postGCF-PGE2 levels of the SAI group(<i>p</i> = 0.0335). Both postGCF-PE2 and IL-6 levels of the PUI group were significantly decreased after treatment(<i>p</i> &lt; 0.0001), while only postGCF-PE2 levels decreased in the SAI group(<i>p</i> = 0.0316). The PUI system significantly reduced PGE2 and IL-6 levels by better controlling inflammation in the treatment of AP.</p>

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Comparison of passive ultrasonic and sonically activated irrigation methods: an investigation based on PGE2, NO and IL-6 levels

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月3日

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  • Seyda Ersahan,
  • Fatih Ozcelik,
  • Sertan Fındıkçı,
  • Yelda Erdem Hepsenoglu,
  • Duygu Degirmencioglu,
  • Aslı Usta

摘要

The effectiveness of Passive Ultrasonic Irrigation(PUI) and Sonically Activated Irrigation(SAI) techniques was investigated in apical periodontitis(AP) patients based on changes in prostaglandin E2(PGE2), nitric oxide(NO), and interleukin-6(IL-6) levels. Sixty-six AP patients and thirty healthy controls were enrolled. Preoperative gingival crevicular fluid(preGCF) PGE2, NO and IL-6 levels were measured before treatment. After chemo-mechanical preparation, teeth were assigned into two groups according to final irrigation protocol[PUI(n:33) and SAI(n:33)]. The same markers were again measured 1 week after treatment(postGCF) and also 1st order most commonly seen bacteria(FMCB) typing was performed on microbial samples of the patients. PostGCF-PGE2 levels of the PUI group were lower than postGCF-PGE2 levels of the SAI group(p = 0.0335). Both postGCF-PE2 and IL-6 levels of the PUI group were significantly decreased after treatment(p < 0.0001), while only postGCF-PE2 levels decreased in the SAI group(p = 0.0316). The PUI system significantly reduced PGE2 and IL-6 levels by better controlling inflammation in the treatment of AP.