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Background <p>Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa with a certain tendency for malignant transformation. The etiology and pathogenesis of OLP remain unclear, and the relationship between psychiatric factors and the development of OLP has attracted much attention in recent years. This study aims to investigate the alterations in oral microbiota and metabolites in OLP patients with psychiatric symptoms, providing a theoretical foundation for understanding the pathogenesis and treatment of OLP.</p> Methods <p>16S rRNA sequencing was used to evaluate the oral microbial population in a cohort of 105 OLP patients. To further investigate the potential interaction between OLP and psychiatric factors, saliva samples from 64 depressed/anxious OLP patients (D-OLP) and their age-matched healthy controls were selected for 16S rRNA sequencing. The salivary metabolome was also characterized by ultra performance liquid chromatography-mass spectrometry (LC-MS).</p> Results <p>The results of 16S rRNA sequencing showed that significant differences in species classification between OLP patients and healthy controls. The D-OLP group displayed an increased abundance of <i>Pseudomonas</i> as well as dysregulation of associated metabolism activities. Correlation analysis showed that the altered metabolites were involved in the metabolic pathways related to the oral-microbiome-brain axis and affected various physiological processes such as neurotransmitter transmission and oxidative stress, promoting epithelial inflammatory activation and immune responses. These changes ultimately lead to the destruction of the original oral mucosal homeostasis.</p> Conclusions <p>Psychiatric factors may promote mucosal inflammatory responses through dysbiosis of the microbiota. The dysregulated oral microbiome-related metabolites may significantly affect the pathogenesis of the oral-brain axis in OLP patients.This study provides valuable insights into potential future modalities for elucidating the pathogenesis of OLP, offering a foundation for the development of personalized therapeutic strategies.</p>

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Variations in salivary microbiota and metabolic phenotype related to oral lichen planus with psychiatric symptoms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月2日

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  • Kuichi Chen,
  • Yuqi Qin,
  • Li Yan,
  • Yunmei Dong,
  • Shiping Lv,
  • Jingyi Xu,
  • Ning Kang,
  • Zhuoyan Luo,
  • Yiyun Liu,
  • Juncai Pu,
  • Fangchun Chen,
  • Xin Jin

摘要

Background

Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa with a certain tendency for malignant transformation. The etiology and pathogenesis of OLP remain unclear, and the relationship between psychiatric factors and the development of OLP has attracted much attention in recent years. This study aims to investigate the alterations in oral microbiota and metabolites in OLP patients with psychiatric symptoms, providing a theoretical foundation for understanding the pathogenesis and treatment of OLP.

Methods

16S rRNA sequencing was used to evaluate the oral microbial population in a cohort of 105 OLP patients. To further investigate the potential interaction between OLP and psychiatric factors, saliva samples from 64 depressed/anxious OLP patients (D-OLP) and their age-matched healthy controls were selected for 16S rRNA sequencing. The salivary metabolome was also characterized by ultra performance liquid chromatography-mass spectrometry (LC-MS).

Results

The results of 16S rRNA sequencing showed that significant differences in species classification between OLP patients and healthy controls. The D-OLP group displayed an increased abundance of Pseudomonas as well as dysregulation of associated metabolism activities. Correlation analysis showed that the altered metabolites were involved in the metabolic pathways related to the oral-microbiome-brain axis and affected various physiological processes such as neurotransmitter transmission and oxidative stress, promoting epithelial inflammatory activation and immune responses. These changes ultimately lead to the destruction of the original oral mucosal homeostasis.

Conclusions

Psychiatric factors may promote mucosal inflammatory responses through dysbiosis of the microbiota. The dysregulated oral microbiome-related metabolites may significantly affect the pathogenesis of the oral-brain axis in OLP patients.This study provides valuable insights into potential future modalities for elucidating the pathogenesis of OLP, offering a foundation for the development of personalized therapeutic strategies.