Scholarlink

Background <p>Genetic factors significantly influence caries development and the colonization of oral bacteria, which could explain why some individuals are more prone or resistant to caries. Human leukocyte antigen (HLA) class II is a component in the adaptive immune system that has been associated with the colonization of oral bacteria such as <i>Streptococcus mutans</i>. This study aimed to investigate the association between specific alleles and genotypes of HLA-DRB1 on subgroup level and the colonization of <i>S. mutans</i> in a group of Swedish children.</p> Methods <p>Blood samples from 357 children were analyzed for HLA using next generation sequencing. Saliva samples were collected and analyzed for <i>S. mutans</i>, after which the subjects were divided into three groups: low, moderate, and high levels of colony forming units (CFU). The frequency of DRB1 alleles and genotypes was compared between the three groups. In addition, colonization levels, including the extremely high and low <i>S. mutans</i> CFU in individuals with alleles DRB1*0401, *0404, and *0301 were compared to the rest of the material.</p> Results <p>Individuals with DRB1*0401 were significantly associated with the extremely high CFU levels, since CFU levels &gt; 100 were observed in 4.3% of individuals with DRB1*0401, compared to none among those without the allele (<i>p</i> = 0.009, Fisher’s exact test). No statistical association was noted between the low, moderate, and high <i>S. mutans</i> groups and specific alleles or genotypes.</p> Conclusions <p>The findings suggest a potential relation between HLA class II alleles and the colonization of <i>S. mutans.</i> Specifically, carrying the DRB1*0401 allele may be a predisposing factor for higher levels of colonization.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

HLA-DRB1 alleles and salivary Streptococcus mutans colonization in a group of Swedish children

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月27日

查看全文
  • Hanna Hänel,
  • Dan Ericson,
  • Marie Louise Wallengren

摘要

Background

Genetic factors significantly influence caries development and the colonization of oral bacteria, which could explain why some individuals are more prone or resistant to caries. Human leukocyte antigen (HLA) class II is a component in the adaptive immune system that has been associated with the colonization of oral bacteria such as Streptococcus mutans. This study aimed to investigate the association between specific alleles and genotypes of HLA-DRB1 on subgroup level and the colonization of S. mutans in a group of Swedish children.

Methods

Blood samples from 357 children were analyzed for HLA using next generation sequencing. Saliva samples were collected and analyzed for S. mutans, after which the subjects were divided into three groups: low, moderate, and high levels of colony forming units (CFU). The frequency of DRB1 alleles and genotypes was compared between the three groups. In addition, colonization levels, including the extremely high and low S. mutans CFU in individuals with alleles DRB1*0401, *0404, and *0301 were compared to the rest of the material.

Results

Individuals with DRB1*0401 were significantly associated with the extremely high CFU levels, since CFU levels > 100 were observed in 4.3% of individuals with DRB1*0401, compared to none among those without the allele (p = 0.009, Fisher’s exact test). No statistical association was noted between the low, moderate, and high S. mutans groups and specific alleles or genotypes.

Conclusions

The findings suggest a potential relation between HLA class II alleles and the colonization of S. mutans. Specifically, carrying the DRB1*0401 allele may be a predisposing factor for higher levels of colonization.