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Background <p>Epilepsy is a neurological disorder characterized by recurrent seizures and antiepileptic drug (AED) therapy is used in treatment. AED therapy have significant adverse effects as osteopenia, osteoporosis and reduced bone mineral density (BMD).</p> Purpose <p>The objective of this study is to evaluate the potential effects of AEDs on the trabecular of the mandible by classifying the drugs according to their ability to induce enzymes and comparing them with those of healthy people using fractal analysis.</p> Materials and methods <p>In this study, dental records of 70 patients (35 AED users and 35 control group) were used. Additionally, the study group was further investigated for the presence of enzyme inducing mechanism. Fractal analysis (FA), panoramic mandibular index (PMI), mandibular cortical width (MCW), and Klemetti index (KI) measurements were performed on panoramic radiographs.</p> Results <p>No statistically significant difference was observed between the study and control groups in terms of FA results and MCW, PMI and KI. There was not a statistically significant difference between AED subgroups, either.</p> Conclusion <p>The findings of this study indicate that the microstructural changes and panoramic morphometric indices of the mandible of AED users do not differ from those observed in healthy subjects.</p> Clinical trial number <p>Not applicable.</p>

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Evaluation of mandibular bone quality with respect to enzyme inducement potential of antiepileptic drugs via fractal analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月29日

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  • Alican Kuran,
  • Umut Seki,
  • Sule Batu,
  • Aytac Uzel,
  • Enver Alper Sinanoglu

摘要

Background

Epilepsy is a neurological disorder characterized by recurrent seizures and antiepileptic drug (AED) therapy is used in treatment. AED therapy have significant adverse effects as osteopenia, osteoporosis and reduced bone mineral density (BMD).

Purpose

The objective of this study is to evaluate the potential effects of AEDs on the trabecular of the mandible by classifying the drugs according to their ability to induce enzymes and comparing them with those of healthy people using fractal analysis.

Materials and methods

In this study, dental records of 70 patients (35 AED users and 35 control group) were used. Additionally, the study group was further investigated for the presence of enzyme inducing mechanism. Fractal analysis (FA), panoramic mandibular index (PMI), mandibular cortical width (MCW), and Klemetti index (KI) measurements were performed on panoramic radiographs.

Results

No statistically significant difference was observed between the study and control groups in terms of FA results and MCW, PMI and KI. There was not a statistically significant difference between AED subgroups, either.

Conclusion

The findings of this study indicate that the microstructural changes and panoramic morphometric indices of the mandible of AED users do not differ from those observed in healthy subjects.

Clinical trial number

Not applicable.