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Background <p>To assess the effectiveness of low-dose amitriptyline in reducing pain and improving oral health-related quality of life in individuals with chronic temporomandibular disorders (TMD) over a 2-month period, compared to placebo.</p> Methods <p>Forty participants were randomly assigned to receive either 25&#xa0;mg of amitriptyline or a placebo pill for 2&#xa0;months. The primary outcome was pain intensity, measured using a visual analogue scale (VAS). The secondary outcome was the impact of pain on oral health-related quality of life, assessed by the Oral Health Impact Profile questionnaire (OHIP-14). Evaluations were conducted at baseline and after the 1st and 2nd months of treatment.</p> Results <p>No statistically significant differences were observed between the treatment groups at baseline (<i>p</i> &gt; 0.05). After 2&#xa0;months of treatment participants in amitriptyline group experienced a significantly greater reduction in spontaneous pain, with a 63.3% decrease in VAS scores. Participants in placebo group showed a much smaller reduction in spontaneous pain, with only a 16.2% decrease in VAS scores. Additionally, the amitriptyline group demonstrated a significant improvement in OHIP-14 scores (<i>p</i> &lt; 0.001), whereas the placebo group showed no significant change in oral health-related quality of life (<i>p</i> = 0.184).</p> Conclusion <p>This study highlights low-dose amitriptyline as an effective treatment for chronic TMD, showing significant pain reduction and improved quality of life, underscoring its value in a multimodal approach despite the need for further research to personalize care.</p> Trial registration <p>This study was registered retrospectively in ISRCTNregistry under the number ISRCTN17622685, on 01/10/2024.</p>

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Evaluating amitriptyline’s role in chronic TMD management: a placebo-controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月4日

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  • Ratka Borić Brakus,
  • Ivan Brakus,
  • Andreja Carek,
  • Tea Galić,
  • Iva Z. Alajbeg

摘要

Background

To assess the effectiveness of low-dose amitriptyline in reducing pain and improving oral health-related quality of life in individuals with chronic temporomandibular disorders (TMD) over a 2-month period, compared to placebo.

Methods

Forty participants were randomly assigned to receive either 25 mg of amitriptyline or a placebo pill for 2 months. The primary outcome was pain intensity, measured using a visual analogue scale (VAS). The secondary outcome was the impact of pain on oral health-related quality of life, assessed by the Oral Health Impact Profile questionnaire (OHIP-14). Evaluations were conducted at baseline and after the 1st and 2nd months of treatment.

Results

No statistically significant differences were observed between the treatment groups at baseline (p > 0.05). After 2 months of treatment participants in amitriptyline group experienced a significantly greater reduction in spontaneous pain, with a 63.3% decrease in VAS scores. Participants in placebo group showed a much smaller reduction in spontaneous pain, with only a 16.2% decrease in VAS scores. Additionally, the amitriptyline group demonstrated a significant improvement in OHIP-14 scores (p < 0.001), whereas the placebo group showed no significant change in oral health-related quality of life (p = 0.184).

Conclusion

This study highlights low-dose amitriptyline as an effective treatment for chronic TMD, showing significant pain reduction and improved quality of life, underscoring its value in a multimodal approach despite the need for further research to personalize care.

Trial registration

This study was registered retrospectively in ISRCTNregistry under the number ISRCTN17622685, on 01/10/2024.