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Objective <p>This meta-analysis aimed to specifically investigate whether diabetes mellitus increases the risk of non-target lesion revascularization (NTLR) following percutaneous coronary intervention (PCI), and to assess whether glycemic control and follow-up duration influence this risk.</p> Methods <p>A comprehensive electronic search was conducted using PubMed, EMBASE, and the Cochrane Library, covering publications from January 1990 to July 2024. Only studies published in English were included to ensure clarity and relevance. Our meta-analysis aimed to assess the differential outcomes of NTLR between patients with and without diabetes mellitus (DM). A fixed-effect model was used to calculate relative risks (RR) and 95% confidence intervals (CIs). Additionally, the quality of the evidence was rigorously assessed using the GRADE methodology, which allowed us to evaluate the reliability of the findings.</p> Results <p>This study included 9295 individuals from five randomized controlled trials (RCTs). Patients with DM had a significantly higher likelihood of undergoing NTLR following PCI compared to non-diabetic patients (RR = 1.14; 95% CI: 1.01–1.28; <i>p</i> = 0.03).</p> Conclusions <p>Our findings highlight that DM is associated with an increased risk of NTLR. By quantifying this risk, this meta-analysis demonstrated that individuals diagnosed with DM exhibit a greater susceptibility to non-target lesion revascularization following PCI. (PROSPERO Registration number: CRD42024588296).</p> Clinical trial number <p>Not applicable.</p>

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Does diabetes affect the incidence of non-target lesion revascularization? A meta-analysis of data from randomized controlled trials

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月6日

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  • Yi Ji,
  • Jiaxin Zhou,
  • Zhen Lian,
  • Binbing Shi,
  • Yanqing Pan,
  • Yuan Yin,
  • Jie Liu,
  • Guoping Zhao,
  • Changxi Zhang,
  • Hong Zhu,
  • Defeng Pan

摘要

Objective

This meta-analysis aimed to specifically investigate whether diabetes mellitus increases the risk of non-target lesion revascularization (NTLR) following percutaneous coronary intervention (PCI), and to assess whether glycemic control and follow-up duration influence this risk.

Methods

A comprehensive electronic search was conducted using PubMed, EMBASE, and the Cochrane Library, covering publications from January 1990 to July 2024. Only studies published in English were included to ensure clarity and relevance. Our meta-analysis aimed to assess the differential outcomes of NTLR between patients with and without diabetes mellitus (DM). A fixed-effect model was used to calculate relative risks (RR) and 95% confidence intervals (CIs). Additionally, the quality of the evidence was rigorously assessed using the GRADE methodology, which allowed us to evaluate the reliability of the findings.

Results

This study included 9295 individuals from five randomized controlled trials (RCTs). Patients with DM had a significantly higher likelihood of undergoing NTLR following PCI compared to non-diabetic patients (RR = 1.14; 95% CI: 1.01–1.28; p = 0.03).

Conclusions

Our findings highlight that DM is associated with an increased risk of NTLR. By quantifying this risk, this meta-analysis demonstrated that individuals diagnosed with DM exhibit a greater susceptibility to non-target lesion revascularization following PCI. (PROSPERO Registration number: CRD42024588296).

Clinical trial number

Not applicable.