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Background <p>Obesity and elevated blood pressure at a young age can lead to serious health complications later in life. The prevalence of both conditions is rising rapidly in both developing and developed countries. However, limited information is available regarding the association between serum uric acid (SUA), obesity, and elevated blood pressure in young adults. Therefore, this study aimed to investigate the relationships among SUA, general and abdominal obesity, and elevated blood pressure in Bangladeshi young adults.</p> Methods <p>In this cross-sectional study, blood samples were collected from 461 young adults (281 males and 180 females) aged 18–28 years. Levels of SUA, fasting blood glucose (FBG), and lipid profile parameters (TG, TC, LDL-C, and HDL-C) were measured using standard colorimetric methods. Participants were divided into four quartiles based on SUA concentrations. Multiple logistic regression analyses were performed to evaluate the associations of SUA with both types of obesity and elevated blood pressure.</p> Results <p>The overall prevalence of hyperuricemia was 25.4%, with 28.5% in males and 20.6% in females. The mean SUA level was significantly higher in males (6.7 ± 1.5&#xa0;mg/dL) than in females (5.3 ± 1.3&#xa0;mg/dL) (<i>p</i> &lt; 0.01). The prevalence of general obesity increased significantly across the SUA quartiles (7.7%, 17.3%, 19.2%, and 55.8%, respectively, <i>p</i> &lt; 0.001). An increasing trend in abdominal obesity prevalence was also observed across the SUA quartiles, except quartile 3 (22.6%, 25.0%, 19.6%, and 32.7%, respectively, <i>p</i> &lt; 0.05). Similarly, a rising trend in elevated blood pressure prevalence was found with higher SUA across the SUA quartiles (17.8%, 24.1%, 26.6%, and 31.5%, respectively, <i>p</i> &lt; 0.001). Males had a comparatively higher prevalence of both types of obesity and elevated blood pressure than their female counterparts. SUA levels were significantly and positively correlated with SBP, DBP, BMI, WC, and HC (<i>p</i> &lt; 0.01 for all). In the regression models, SUA remained positively and significantly associated with both general and abdominal obesity, as well as elevated blood pressure, after adjustment for confounders.</p> Conclusions <p>The findings indicate that the prevalence of obesity and elevated blood pressure increases with higher SUA levels. Elevated SUA was positively associated with both general and abdominal obesity as well as elevated blood pressure in this population. Effective management of SUA, along with controlling obesity and blood pressure, may help prevent related health complications in young adults.</p> Clinical trial number <p>Not applicable.</p>

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Serum uric acid and its association with general and abdominal obesity and elevated blood pressure among young adults in Sylhet division, Bangladesh

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月27日

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  • Firoz Mahmud,
  • Nusrat Jahan Koley,
  • Khandaker Atkia Fariha,
  • Nurshad Ali

摘要

Background

Obesity and elevated blood pressure at a young age can lead to serious health complications later in life. The prevalence of both conditions is rising rapidly in both developing and developed countries. However, limited information is available regarding the association between serum uric acid (SUA), obesity, and elevated blood pressure in young adults. Therefore, this study aimed to investigate the relationships among SUA, general and abdominal obesity, and elevated blood pressure in Bangladeshi young adults.

Methods

In this cross-sectional study, blood samples were collected from 461 young adults (281 males and 180 females) aged 18–28 years. Levels of SUA, fasting blood glucose (FBG), and lipid profile parameters (TG, TC, LDL-C, and HDL-C) were measured using standard colorimetric methods. Participants were divided into four quartiles based on SUA concentrations. Multiple logistic regression analyses were performed to evaluate the associations of SUA with both types of obesity and elevated blood pressure.

Results

The overall prevalence of hyperuricemia was 25.4%, with 28.5% in males and 20.6% in females. The mean SUA level was significantly higher in males (6.7 ± 1.5 mg/dL) than in females (5.3 ± 1.3 mg/dL) (p < 0.01). The prevalence of general obesity increased significantly across the SUA quartiles (7.7%, 17.3%, 19.2%, and 55.8%, respectively, p < 0.001). An increasing trend in abdominal obesity prevalence was also observed across the SUA quartiles, except quartile 3 (22.6%, 25.0%, 19.6%, and 32.7%, respectively, p < 0.05). Similarly, a rising trend in elevated blood pressure prevalence was found with higher SUA across the SUA quartiles (17.8%, 24.1%, 26.6%, and 31.5%, respectively, p < 0.001). Males had a comparatively higher prevalence of both types of obesity and elevated blood pressure than their female counterparts. SUA levels were significantly and positively correlated with SBP, DBP, BMI, WC, and HC (p < 0.01 for all). In the regression models, SUA remained positively and significantly associated with both general and abdominal obesity, as well as elevated blood pressure, after adjustment for confounders.

Conclusions

The findings indicate that the prevalence of obesity and elevated blood pressure increases with higher SUA levels. Elevated SUA was positively associated with both general and abdominal obesity as well as elevated blood pressure in this population. Effective management of SUA, along with controlling obesity and blood pressure, may help prevent related health complications in young adults.

Clinical trial number

Not applicable.