Scholarlink

Background <p>The majority of diabetes cases fall into type 2 diabetes mellitus (T2DM), which is prone to chronic complications that have a long-term impact on patients. The aim of this study was to investigate the diagnostic potential of miR-214-3p in T2DM and its predictive value for chronic complications, providing a novel biomarker for the disease.</p> Methods <p>A total of 156 patients with T2DM and 80 non-T2DM individuals were included. Serum miR-214-3p levels were measured by real-time reverse transcription quantitative PCR (RT-qPCR). The correlation of miR-214-3p with hemoglobin A1c (HbA1c) and low-density lipoprotein cholesterol (LDL-C) was analyzed by Spearman’s rank correlation. The clinical value of miR-214-3p in T2DM was evaluated using the receiver operating characteristic (ROC) curve and logistic regression analysis.</p> Results <p>The serum levels of miR-214-3p were decreased in T2DM patients compared to non-T2DM individuals. A negative correlation was identified between miR-214-3p expression and the levels of HbA1c and LDL-C. miR-214-3p could effectively differentiate T2DM patients from non-T2DM individuals with the area under ROC curve (AUC) of 0.884. Patients with low miR-214-3p expression had a higher incidence of chronic complications. The AUC for miR-214-3p in differentiating between T2DM patients with and without complications was 0.832. Low expression of miR-214-3p was a risk factor linked to the development of chronic complications in patients with T2DM.</p> Conclusion <p>Serum miR-214-3p was downregulated in T2DM and could differentiate T2DM patients from non-T2DM individuals. miR-214-3p was a promising biomarker for predicting the chronic complications of T2DM.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical value of serum miR-214-3p expression in the diagnosis of type 2 diabetes mellitus and prediction of its chronic complications

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月14日

查看全文
  • Meng Ding,
  • Siyu Yang,
  • Junli Li,
  • Lie Ma,
  • Cunyou Xiong,
  • Jie Zhang

摘要

Background

The majority of diabetes cases fall into type 2 diabetes mellitus (T2DM), which is prone to chronic complications that have a long-term impact on patients. The aim of this study was to investigate the diagnostic potential of miR-214-3p in T2DM and its predictive value for chronic complications, providing a novel biomarker for the disease.

Methods

A total of 156 patients with T2DM and 80 non-T2DM individuals were included. Serum miR-214-3p levels were measured by real-time reverse transcription quantitative PCR (RT-qPCR). The correlation of miR-214-3p with hemoglobin A1c (HbA1c) and low-density lipoprotein cholesterol (LDL-C) was analyzed by Spearman’s rank correlation. The clinical value of miR-214-3p in T2DM was evaluated using the receiver operating characteristic (ROC) curve and logistic regression analysis.

Results

The serum levels of miR-214-3p were decreased in T2DM patients compared to non-T2DM individuals. A negative correlation was identified between miR-214-3p expression and the levels of HbA1c and LDL-C. miR-214-3p could effectively differentiate T2DM patients from non-T2DM individuals with the area under ROC curve (AUC) of 0.884. Patients with low miR-214-3p expression had a higher incidence of chronic complications. The AUC for miR-214-3p in differentiating between T2DM patients with and without complications was 0.832. Low expression of miR-214-3p was a risk factor linked to the development of chronic complications in patients with T2DM.

Conclusion

Serum miR-214-3p was downregulated in T2DM and could differentiate T2DM patients from non-T2DM individuals. miR-214-3p was a promising biomarker for predicting the chronic complications of T2DM.