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Background <p>This study evaluates the efficacy of pancreatic stump binding and ligation (PSBL) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).</p> Methods <p>A retrospective cohort analysis included 217 patients undergoing DP between 2015 and 2022. Patients were classified into two groups: those receiving PSBL (B-Group, <i>n</i> = 96) and those without (NB-Group, <i>n</i> = 121). The primary outcome was incidence of clinically relevant POPF (Grade B/C).</p> Results <p>The B-Group demonstrated lower POPF rates (11.5% vs. 28.9%, <i>P</i> = 0.003) compared to the NB-Group, with grade B fistulas particularly reduced (<i>P</i> = 0.002). Multivariate analysis identified independent risk factors for POPF: BMI ≥ 28&#xa0;kg/m<sup>2</sup> (OR = 14.105, <i>P</i> &lt; 0.001), Preoperative Hypoalbuminemia (OR = 7.031, <i>P</i> &lt; 0.001), Manual Method of Stump Closure (OR = 2.558, <i>P</i> = 0.020), and non-PSBL Technique (OR = 4.463, <i>P</i> &lt; 0.001).</p> Conclusions <p>In this retrospective cohort, PSBL is a promising, feasible technique associated with reduced clinically relevant POPF incidence after DP. Given the retrospective design, these findings are hypothesis-generating and warrant prospective, multicenter validation.</p>

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Evaluation of pancreatic stump binding and ligation in reducing postoperative pancreatic fistula after distal pancreatectomy: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月18日

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  • Zi-Ang Jiang,
  • Xiang-Yu Lu,
  • Hang Deng,
  • Xu Wang,
  • Jian Xu,
  • Jie Zhang,
  • Yao Zhou,
  • Jun Gong,
  • Ke Dong,
  • Yan Dai,
  • Hao Zhang

摘要

Background

This study evaluates the efficacy of pancreatic stump binding and ligation (PSBL) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).

Methods

A retrospective cohort analysis included 217 patients undergoing DP between 2015 and 2022. Patients were classified into two groups: those receiving PSBL (B-Group, n = 96) and those without (NB-Group, n = 121). The primary outcome was incidence of clinically relevant POPF (Grade B/C).

Results

The B-Group demonstrated lower POPF rates (11.5% vs. 28.9%, P = 0.003) compared to the NB-Group, with grade B fistulas particularly reduced (P = 0.002). Multivariate analysis identified independent risk factors for POPF: BMI ≥ 28 kg/m2 (OR = 14.105, P < 0.001), Preoperative Hypoalbuminemia (OR = 7.031, P < 0.001), Manual Method of Stump Closure (OR = 2.558, P = 0.020), and non-PSBL Technique (OR = 4.463, P < 0.001).

Conclusions

In this retrospective cohort, PSBL is a promising, feasible technique associated with reduced clinically relevant POPF incidence after DP. Given the retrospective design, these findings are hypothesis-generating and warrant prospective, multicenter validation.