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Background <p>This study aimed to summarize the clinical characteristics and long-term surgical outcomes of infants younger than 6&#xa0;months with anomalous origin of one pulmonary artery from the aorta (AOPA) and to identify factors associated with reoperation.</p> Methods <p>Infants younger than 6&#xa0;months who underwent surgical repair for AOPA between January 2013 and December 2020 were retrospectively included. Long-term follow-up data were analyzed. Patients were stratified according to reoperation status and use of patch reconstruction during the primary operation, and preoperative, intraoperative, and postoperative variables were compared.</p> Results <p>Fifteen infants were enrolled, including 14 with anomalous origin of the right pulmonary artery and 1 with anomalous origin of the left pulmonary artery. All survived to hospital discharge. The median follow-up time was 65&#xa0;months (IQR 39–97&#xa0;months). During follow-up, reimplanted pulmonary artery branches remained smaller than normal. Five patients (33.3%) required reintervention. Patients in the reoperation group had lower preoperative pulmonary artery z scores. In the patch-repaired group, abnormal pulmonary artery branches had lower z scores and higher flow velocities at first discharge. Patients operated on at ≤ 1&#xa0;month of age had a higher risk of reoperation and demonstrated smaller pulmonary artery z scores and faster flow velocities at first discharge.</p> Conclusions <p>Surgical repair of AOPA in early infancy yields favorable outcomes. Younger age at surgery and smaller branch pulmonary arteries are associated with an increased risk of reoperation.</p>

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Long-term outcomes after surgical repair of anomalous origin of one pulmonary artery from the aorta in infants younger than 6 months

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Yu Zhu,
  • Yixuan Cai,
  • Ming Ye,
  • Gang Chen,
  • Xiao Shen,
  • Huifeng Zhang,
  • Yaping Mi

摘要

Background

This study aimed to summarize the clinical characteristics and long-term surgical outcomes of infants younger than 6 months with anomalous origin of one pulmonary artery from the aorta (AOPA) and to identify factors associated with reoperation.

Methods

Infants younger than 6 months who underwent surgical repair for AOPA between January 2013 and December 2020 were retrospectively included. Long-term follow-up data were analyzed. Patients were stratified according to reoperation status and use of patch reconstruction during the primary operation, and preoperative, intraoperative, and postoperative variables were compared.

Results

Fifteen infants were enrolled, including 14 with anomalous origin of the right pulmonary artery and 1 with anomalous origin of the left pulmonary artery. All survived to hospital discharge. The median follow-up time was 65 months (IQR 39–97 months). During follow-up, reimplanted pulmonary artery branches remained smaller than normal. Five patients (33.3%) required reintervention. Patients in the reoperation group had lower preoperative pulmonary artery z scores. In the patch-repaired group, abnormal pulmonary artery branches had lower z scores and higher flow velocities at first discharge. Patients operated on at ≤ 1 month of age had a higher risk of reoperation and demonstrated smaller pulmonary artery z scores and faster flow velocities at first discharge.

Conclusions

Surgical repair of AOPA in early infancy yields favorable outcomes. Younger age at surgery and smaller branch pulmonary arteries are associated with an increased risk of reoperation.