Scholarlink

Background <p>Perforated peptic ulcer is a critical emergency disease requiring surgery, and postoperative intra-abdominal abscess (IAA), an organ/space surgical site infection (SSI), is a common complication. Intraoperative irrigation is a common IAA prevention approach; however, scientific evidence supporting its effectiveness is lacking. We aimed to investigate the association between intraoperative irrigation volume and IAA using multicentre data.</p> Methods <p>This multicentre retrospective cohort study was conducted between January 2011 and December 2023. The study included patients aged ≥ 18&#xa0;years who underwent laparotomy or laparoscopy for perforated peptic ulcer, defined as perforation of a gastric or duodenal ulcer. The primary and secondary outcomes were IAA incidence and superficial incisional SSI, respectively, and their association with the intraoperative irrigation volume was determined through multivariable logistic regression analyses.</p> Results <p>The study included 478 patients with a median age of 66&#xa0;years (interquartile range [IQR]: 54–75&#xa0;years), 344 (72.0%) of whom were males. The median irrigation volume was 7.0 (IQR: 5–10) L. Among the 478 patients, IAA and superficial incisional SSI occurred in 52 (10.9%) and 71 (14.9%), respectively. The irrigation volume and the outcomes exhibited no significant association (for IAA: adjusted odds ratio [AOR] = 1.04, 95% confidence interval [CI] = 0.97–1.11, <i>p</i> = 0.25; for superficial incisional SSI: AOR = 1.07, 95% CI = 1.00–1.14, <i>p</i> = 0.053).</p> Conclusions <p>There was no statistically significant association between increased intraoperative irrigation volume and a decreased incidence of postoperative IAA formation. These findings suggest that alternative strategies, rather than uncontrolled high-volume irrigation, are required for IAA prevention.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between intraoperative irrigation volume and postoperative abdominal abscess in perforated peptic ulcer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月6日

查看全文
  • Atsushi Tabeta,
  • Yusuke Tsutsumi,
  • Hiromasa Hoshi,
  • Akira Endo,
  • Koji Ito,
  • Tomohiro Akutsu,
  • Hikaru Odera,
  • Hideto Shiraki,
  • Kei Ito,
  • Takeshi Yokoyama,
  • Yasukazu Narita,
  • Taro Masuda,
  • Akira Suekane,
  • Koji Morishita

摘要

Background

Perforated peptic ulcer is a critical emergency disease requiring surgery, and postoperative intra-abdominal abscess (IAA), an organ/space surgical site infection (SSI), is a common complication. Intraoperative irrigation is a common IAA prevention approach; however, scientific evidence supporting its effectiveness is lacking. We aimed to investigate the association between intraoperative irrigation volume and IAA using multicentre data.

Methods

This multicentre retrospective cohort study was conducted between January 2011 and December 2023. The study included patients aged ≥ 18 years who underwent laparotomy or laparoscopy for perforated peptic ulcer, defined as perforation of a gastric or duodenal ulcer. The primary and secondary outcomes were IAA incidence and superficial incisional SSI, respectively, and their association with the intraoperative irrigation volume was determined through multivariable logistic regression analyses.

Results

The study included 478 patients with a median age of 66 years (interquartile range [IQR]: 54–75 years), 344 (72.0%) of whom were males. The median irrigation volume was 7.0 (IQR: 5–10) L. Among the 478 patients, IAA and superficial incisional SSI occurred in 52 (10.9%) and 71 (14.9%), respectively. The irrigation volume and the outcomes exhibited no significant association (for IAA: adjusted odds ratio [AOR] = 1.04, 95% confidence interval [CI] = 0.97–1.11, p = 0.25; for superficial incisional SSI: AOR = 1.07, 95% CI = 1.00–1.14, p = 0.053).

Conclusions

There was no statistically significant association between increased intraoperative irrigation volume and a decreased incidence of postoperative IAA formation. These findings suggest that alternative strategies, rather than uncontrolled high-volume irrigation, are required for IAA prevention.