Scholarlink

Background <p>The “pan-gate theory”, an innovative extension of the “gate theory,” optimizes Laennec’s approach in laparoscopic liver resection (LLR) by increasing adaptability to anatomical variations and facilitating rapid isolation of the target hepatic pedicle for precise regional inflow occlusion. This study evaluated the safety and feasibility of the “pan-gate theory” in LLR for hepatocellular carcinoma (HCC), with a focus on technical advantages and postoperative outcomes.</p> Methods <p>This was a single-arm retrospective study of 48 HCC patients who underwent LLR via the pan-gate Theory (June 2022–September 2023). The primary outcomes were operative time and estimated blood loss (EBL). The secondary outcomes included complications, postoperative hospital stay (PHS), and disease-free survival (DFS). The surgical procedure, guided by the pan-gate theory, included entering Laennec’s capsule-Glissonean sheath through the red–yellow demarcation line for regional hepatic inflow occlusion, whereas Laennec’s approach is utilized for parenchymal and hepatic vein management.</p> Results <p>The median operative time was 164 (110–217) min, and the EBL was 100 (50–200) mL. All patients achieved R0 resection without conversion to open surgery. Postoperative complications included bile leakage (Grade B) in 7 patients and controlled bleeding in 1 patient. The median PHS was 7.5 (5.6–10.4) days. The one-year DFS rate was 87.5%, with zero mortality. Postoperative quality of life (EORTC QLQ-C30) improved across dimensions.</p> Conclusion <p>Pan-gate theory demonstrates the safety and feasibility of LLR for the treatment of HCC, indicating that LLR is superior in terms of anatomical variation management. It results in short operative times, minimal blood loss, and few complications, with favourable long-term outcomes. Multicenter studies are needed to validate these findings and optimize their clinical application.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The safety and feasibility of the “pan-gate theory” in laparoscopic liver resection through laennec’s approach combined with “regional hepatic inflow occlusion” for hepatocellular carcinoma

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月9日

查看全文
  • Chenfenglin Yang,
  • Pinchu Chen,
  • Yao Li,
  • Wen Hu,
  • Shubing Wei,
  • Jieru Ding,
  • Xiao Zhang,
  • Zetong Wang,
  • Qifan Zhang

摘要

Background

The “pan-gate theory”, an innovative extension of the “gate theory,” optimizes Laennec’s approach in laparoscopic liver resection (LLR) by increasing adaptability to anatomical variations and facilitating rapid isolation of the target hepatic pedicle for precise regional inflow occlusion. This study evaluated the safety and feasibility of the “pan-gate theory” in LLR for hepatocellular carcinoma (HCC), with a focus on technical advantages and postoperative outcomes.

Methods

This was a single-arm retrospective study of 48 HCC patients who underwent LLR via the pan-gate Theory (June 2022–September 2023). The primary outcomes were operative time and estimated blood loss (EBL). The secondary outcomes included complications, postoperative hospital stay (PHS), and disease-free survival (DFS). The surgical procedure, guided by the pan-gate theory, included entering Laennec’s capsule-Glissonean sheath through the red–yellow demarcation line for regional hepatic inflow occlusion, whereas Laennec’s approach is utilized for parenchymal and hepatic vein management.

Results

The median operative time was 164 (110–217) min, and the EBL was 100 (50–200) mL. All patients achieved R0 resection without conversion to open surgery. Postoperative complications included bile leakage (Grade B) in 7 patients and controlled bleeding in 1 patient. The median PHS was 7.5 (5.6–10.4) days. The one-year DFS rate was 87.5%, with zero mortality. Postoperative quality of life (EORTC QLQ-C30) improved across dimensions.

Conclusion

Pan-gate theory demonstrates the safety and feasibility of LLR for the treatment of HCC, indicating that LLR is superior in terms of anatomical variation management. It results in short operative times, minimal blood loss, and few complications, with favourable long-term outcomes. Multicenter studies are needed to validate these findings and optimize their clinical application.