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<p>This meta-analysis examines the impact of pathological complete response (pCR) on long-term survival in locally advanced esophageal cancer patients treated with neoadjuvant chemoradiotherapy (NCRT) and surgery. A systematic review of 38 studies found that pCR correlates with improved overall survival (HR = 0.54) and disease-free survival (HR = 0.51). The findings suggest that pCR may serve as a surrogate endpoint for evaluating the survival outcomes of NCRT.</p>

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Does pathological complete response after neoadjuvant chemoradiotherapy associate with long-term survival in esophageal cancer: A systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月16日

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  • Jiajing Sun,
  • Cien Sun,
  • Ying Zhang,
  • Zixian Jin,
  • Thivanka Witharana,
  • Jiawei Li,
  • Chengchu Zhu,
  • Jianfei Shen

摘要

This meta-analysis examines the impact of pathological complete response (pCR) on long-term survival in locally advanced esophageal cancer patients treated with neoadjuvant chemoradiotherapy (NCRT) and surgery. A systematic review of 38 studies found that pCR correlates with improved overall survival (HR = 0.54) and disease-free survival (HR = 0.51). The findings suggest that pCR may serve as a surrogate endpoint for evaluating the survival outcomes of NCRT.