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Aims <p>To determine the most effective resistance training (RT) type and the optimal intensity, duration, and number of repetitions for patients with knee osteoarthritis (KOA).</p> Methods <p>PubMed, MEDLINE, Embase, CENTRAL, and Web of Science were searched from inception to April 2025 for randomized controlled trials (RCTs) of exercise for KOA. Bayesian network meta-analyses were conducted. The outcomes of pain, stiffness, and function were expressed as standardized mean differences (SMDs) with 95% credible intervals (CrI).</p> Results <p>The analysis included 46 RCTs with 3463 participants. High-speed RT was identified as the most effective type, significantly improving pain (SMD: -1.35, 95% CrI: -1.89 to -0.81), stiffness (SMD: -1.26, 95% CrI: -1.81 to -0.70), and function (SMD: 1.70, 95% CrI: 0.96 to 2.45). Dose-response analysis indicated that moderate-intensity RT (43–47% 1RM) for 35–37 weeks with 610–640 weekly repetitions was optimal for reducing pain (SMD: -0.76, 95% CrI: -1.03 to -0.44) and improving function (SMD: 1.29, 95% CrI: 0.92 to 1.68). For stiffness, a higher number of repetitions and shorter duration (12 weeks, 1200 weekly repetitions) were more effective (SMD: -1.11, 95% CrI: -1.58 to -0.64).</p> Conclusions <p>This study identifies high-speed RT as the most effective type for managing KOA and provides optimal RT dosages for different symptoms. These findings emphasize the need for tailored RT programs and provide crucial insights for clinical guidelines and individualized patient care.</p> PROSPERO number <p>CRD42024535806</p>

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Optimal resistance training strategies for knee osteoarthritis symptom relief: a systematic review and network meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月12日

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  • Yong Yang,
  • Junyu Wang,
  • Tao Wang,
  • Yuan Yuan,
  • Bopeng Qiu,
  • Wenke Hu,
  • Fuhong Wang,
  • Zhihong Tang,
  • Shu-Cheng Lin

摘要

Aims

To determine the most effective resistance training (RT) type and the optimal intensity, duration, and number of repetitions for patients with knee osteoarthritis (KOA).

Methods

PubMed, MEDLINE, Embase, CENTRAL, and Web of Science were searched from inception to April 2025 for randomized controlled trials (RCTs) of exercise for KOA. Bayesian network meta-analyses were conducted. The outcomes of pain, stiffness, and function were expressed as standardized mean differences (SMDs) with 95% credible intervals (CrI).

Results

The analysis included 46 RCTs with 3463 participants. High-speed RT was identified as the most effective type, significantly improving pain (SMD: -1.35, 95% CrI: -1.89 to -0.81), stiffness (SMD: -1.26, 95% CrI: -1.81 to -0.70), and function (SMD: 1.70, 95% CrI: 0.96 to 2.45). Dose-response analysis indicated that moderate-intensity RT (43–47% 1RM) for 35–37 weeks with 610–640 weekly repetitions was optimal for reducing pain (SMD: -0.76, 95% CrI: -1.03 to -0.44) and improving function (SMD: 1.29, 95% CrI: 0.92 to 1.68). For stiffness, a higher number of repetitions and shorter duration (12 weeks, 1200 weekly repetitions) were more effective (SMD: -1.11, 95% CrI: -1.58 to -0.64).

Conclusions

This study identifies high-speed RT as the most effective type for managing KOA and provides optimal RT dosages for different symptoms. These findings emphasize the need for tailored RT programs and provide crucial insights for clinical guidelines and individualized patient care.

PROSPERO number

CRD42024535806