Scholarlink

Background <p>This study aimed to explore the causal association between obstructive sleep apnea (OSA) and frailty traits using a bidirectional two-sample Mendelian randomization (MR) analysis.</p> Methods <p>Summary data from large-scale European genome-wide association studies were used to assess the genetic link between OSA and frailty traits, including frailty index, appendicular lean mass, grip strength, and walking pace. Effect estimates were primarily evaluated using inverse-variance weighted (IVW) analysis, complemented by MR-Egger, weighted median (WM), simple mode, and weighted mode analyses. Sensitivity analyses were performed to assess heterogeneity, outliers, and horizontal pleiotropy.</p> Results <p>Forward MR analysis showed no significant effect of OSA on frailty traits. However, reverse MR analysis suggested that a higher frailty index was associated with an increased risk of OSA (IVW: odds ratio [OR], 1.777; 95% confidence interval [CI], 1.137–2.777; <i>p</i> = 0.01) based on 14 single nucleotide polymorphisms (SNPs), and a faster walking pace was identified as a protective factor against OSA (IVW: OR, 0.204; 95% CI, 0.104–0.399; <i>p</i> &lt; 0.01; WM: OR, 0.368; 95% CI, 0.193–0.703; <i>p</i> &lt; 0.01) based on 56 SNPs. No significant pleiotropy was detected, and sensitivity analyses confirmed the robustness of these findings.</p> Conclusion <p>Our MR study provided evidence that frailty traits may have a causal effect on OSA in the European ancestry population, with frailty index increasing the risk and walking pace acting as a protective factor.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The association between obstructive sleep apnea and frailty traits: a bidirectional Mendelian randomization study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月16日

查看全文
  • Jingning Huang,
  • Yunqiu Chu,
  • Xiaozhen Zhang,
  • Zilu Shen,
  • Chenyang Li,
  • Xinyi Li,
  • Yupu Liu,
  • Jianyin Zou,
  • Suru Liu,
  • Kejia Wu,
  • Weijun Huang,
  • Xiaoman Zhang,
  • Huajun Xu,
  • Jian Guan,
  • Hongliang Yi,
  • Xiaoyue Zhu,
  • Shankai Yin

摘要

Background

This study aimed to explore the causal association between obstructive sleep apnea (OSA) and frailty traits using a bidirectional two-sample Mendelian randomization (MR) analysis.

Methods

Summary data from large-scale European genome-wide association studies were used to assess the genetic link between OSA and frailty traits, including frailty index, appendicular lean mass, grip strength, and walking pace. Effect estimates were primarily evaluated using inverse-variance weighted (IVW) analysis, complemented by MR-Egger, weighted median (WM), simple mode, and weighted mode analyses. Sensitivity analyses were performed to assess heterogeneity, outliers, and horizontal pleiotropy.

Results

Forward MR analysis showed no significant effect of OSA on frailty traits. However, reverse MR analysis suggested that a higher frailty index was associated with an increased risk of OSA (IVW: odds ratio [OR], 1.777; 95% confidence interval [CI], 1.137–2.777; p = 0.01) based on 14 single nucleotide polymorphisms (SNPs), and a faster walking pace was identified as a protective factor against OSA (IVW: OR, 0.204; 95% CI, 0.104–0.399; p < 0.01; WM: OR, 0.368; 95% CI, 0.193–0.703; p < 0.01) based on 56 SNPs. No significant pleiotropy was detected, and sensitivity analyses confirmed the robustness of these findings.

Conclusion

Our MR study provided evidence that frailty traits may have a causal effect on OSA in the European ancestry population, with frailty index increasing the risk and walking pace acting as a protective factor.