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Background <p>Aspiration-associated respiratory failure is an important but under-recognized cause of morbidity and mortality among U.S. adults. Despite its clinical significance, national epidemiologic patterns and demographic disparities remain poorly characterized.</p> Methods <p>Mortality data from the CDC WONDER Database (1999–2023) were extracted for adults aged ≥ 25 years in the U.S. with Aspiration and Respiratory Failure listed as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) were calculated. Joinpoint regression was used to estimate the Annual Percent Change (APC) and Annual Average Percentage Change (AAPC) with 95% confidence intervals (CIs).</p> Results <p>Between 1999 and 2023, 372,764 deaths involving aspiration-associated respiratory failure were identified among U.S. adults aged ≥ 25 years. The age-adjusted mortality rate increased from 4.27 to 10.17 per 100,000 population (AAPC: 3.98%; <i>p</i> &lt; 0.001). Males had higher mean AAMRs than females (8.94 vs. 4.72 per 100,000). Adults aged ≥ 65 years had the highest crude mortality rate (27.79 per 100,000). Non-Hispanic African Americans (7.10) and American Indian/Alaska Native populations (6.61) had the highest mean AAMRs, while metropolitan areas had slightly higher AAMRs than non-metropolitan areas (5.99 vs. 5.40).</p> Conclusion <p>Mortality involving aspiration-associated respiratory failure increased significantly from 1999 to 2023, with substantial demographic and geographic disparities. These findings support improved dysphagia prevention, surveillance, and targeted public health interventions.</p>

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Mortality trends of aspiration-associated respiratory failure in the united states : a multiple cause of death analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月4日

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  • Taha Alam,
  • Ehsanullah Alokozay,
  • Sohaima Kamal,
  • FNU Areesha,
  • Muhammad Ibrahim Rashid,
  • Iman Osman Abufatima,
  • Noor Un Nisa,
  • Muhammad Junaid Azhar,
  • Amber Alam,
  • Ali Chand,
  • Nafila Zeeshan,
  • Mahwish Gulbahar,
  • Alem Mehari

摘要

Background

Aspiration-associated respiratory failure is an important but under-recognized cause of morbidity and mortality among U.S. adults. Despite its clinical significance, national epidemiologic patterns and demographic disparities remain poorly characterized.

Methods

Mortality data from the CDC WONDER Database (1999–2023) were extracted for adults aged ≥ 25 years in the U.S. with Aspiration and Respiratory Failure listed as underlying or contributing causes of death. Age-adjusted mortality rates (AAMRs) were calculated. Joinpoint regression was used to estimate the Annual Percent Change (APC) and Annual Average Percentage Change (AAPC) with 95% confidence intervals (CIs).

Results

Between 1999 and 2023, 372,764 deaths involving aspiration-associated respiratory failure were identified among U.S. adults aged ≥ 25 years. The age-adjusted mortality rate increased from 4.27 to 10.17 per 100,000 population (AAPC: 3.98%; p < 0.001). Males had higher mean AAMRs than females (8.94 vs. 4.72 per 100,000). Adults aged ≥ 65 years had the highest crude mortality rate (27.79 per 100,000). Non-Hispanic African Americans (7.10) and American Indian/Alaska Native populations (6.61) had the highest mean AAMRs, while metropolitan areas had slightly higher AAMRs than non-metropolitan areas (5.99 vs. 5.40).

Conclusion

Mortality involving aspiration-associated respiratory failure increased significantly from 1999 to 2023, with substantial demographic and geographic disparities. These findings support improved dysphagia prevention, surveillance, and targeted public health interventions.