Scholarlink

Background <p>Although numerous epidemiological studies have reported significant associations between type 2 diabetes mellitus (T2DM) and breast cancer incidence, considerable heterogeneity exists across studies. Moreover, the breast cancer risk in relation to T2DM duration remains unclear. This study aimed to investigate the associations between T2DM, T2DM duration, and breast cancer risk in Chinese women.</p> Methods <p>A total of 72,295 women aged 40–70 years from the Shanghai Women’s Health Study were included. T2DM was defined as diagnosis after age 30, and categorized as prevalent at enrollment or incident during follow-up. Incident T2DM was treated as a time-dependent exposure in Cox proportional hazards regression models. The risk trajectory of breast cancer following T2DM diagnosis was characterized using categorical modelling analysis.</p> Results <p>Over a median follow-up of 19.08 years, 1,759 incident cases of breast cancer were identified. Compared to individuals without diabetes, overall T2DM was associated with an increased risk of breast cancer (HR = 1.22, 95%CI: 1.05–1.43). This association was significant in women diagnosed with incident T2DM during follow-up (HR = 1.28, 95% CI: 1.05–1.55) but not in those with prevalent T2DM at enrollment (HR = 1.15, 95% CI: 0.90–1.46). A clear trajectory of trend was observed, with the highest risk occurring within the first 5 years after T2DM diagnosis (HR = 4.22, 95% CI: 3.27–5.44).</p> Conclusions <p>T2DM was associated with an elevated breast cancer risk in Chinese women, which peaked at approximately 5 years post-diagnosis. Future studies should collect detailed information on treatment and lifestyle changes in study populations, to enable more in-depth analysis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Association between type 2 diabetes mellitus and breast cancer risk: results from a population-based cohort study in Chinese women

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

查看全文
  • Dan-Dan Tang,
  • Qiu-Ming Shen,
  • Zhuo-Ying Li,
  • Da-Ke Liu,
  • Yu-Ting Tan,
  • Hong-Lan Li,
  • Yong-Bing Xiang

摘要

Background

Although numerous epidemiological studies have reported significant associations between type 2 diabetes mellitus (T2DM) and breast cancer incidence, considerable heterogeneity exists across studies. Moreover, the breast cancer risk in relation to T2DM duration remains unclear. This study aimed to investigate the associations between T2DM, T2DM duration, and breast cancer risk in Chinese women.

Methods

A total of 72,295 women aged 40–70 years from the Shanghai Women’s Health Study were included. T2DM was defined as diagnosis after age 30, and categorized as prevalent at enrollment or incident during follow-up. Incident T2DM was treated as a time-dependent exposure in Cox proportional hazards regression models. The risk trajectory of breast cancer following T2DM diagnosis was characterized using categorical modelling analysis.

Results

Over a median follow-up of 19.08 years, 1,759 incident cases of breast cancer were identified. Compared to individuals without diabetes, overall T2DM was associated with an increased risk of breast cancer (HR = 1.22, 95%CI: 1.05–1.43). This association was significant in women diagnosed with incident T2DM during follow-up (HR = 1.28, 95% CI: 1.05–1.55) but not in those with prevalent T2DM at enrollment (HR = 1.15, 95% CI: 0.90–1.46). A clear trajectory of trend was observed, with the highest risk occurring within the first 5 years after T2DM diagnosis (HR = 4.22, 95% CI: 3.27–5.44).

Conclusions

T2DM was associated with an elevated breast cancer risk in Chinese women, which peaked at approximately 5 years post-diagnosis. Future studies should collect detailed information on treatment and lifestyle changes in study populations, to enable more in-depth analysis.