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Background <p>Snakebite envenoming remains poorly understood in terms of long-term health-related quality of life (HRQoL), particularly in China where standardized assessments are lacking. This study is the first to comprehensively evaluate HRQoL impairments in discharged snakebite patients using the EuroQol 5-Dimension 5-Level (EQ-5D-5&#xa0;L) instrument in China, addressing a critical methodological gap.</p> Methods <p>A multicenter cross-sectional study enrolled 6,528 snakebite patients. HRQoL was assessed via EQ-5D-5&#xa0;L (Chinese value set) and customized surveys. Generalized linear models and XGBoost machine learning identified predictors.</p> Results <p>The mean utility score (0.76 ± 0.27) was significantly lower than China’s general population (0.95). Pain/discomfort (53.6%) and mobility impairment (45.4%) were most prevalent. Machine learning revealed key predictors: post-traumatic stress disorder (PTSD, 34.5%) &gt; number of snakebites (11.7%) &gt; time of arrival at medical institutions (7.9%) &gt; depression (7.8%) &gt; marriage (6.5%).</p> Conclusions <p>This study provides the first EQ-5D-5&#xa0;L-based quantification of the significant HRQoL burden among snakebite survivors in China. Physical impairments predominantly manifest in the mobility and pain/discomfort dimensions, while mental health disorders constitute the primary driver of long-term HRQoL deterioration. Crucially, we identified PTSD, time to medical facility, and bite frequency as modifiable predictors, evidencing their relevance for snakebite prevention and control strategies.</p>

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Unveiling the burden of snakebite injuries: an EQ-5D-5 L-based evaluation of health-related quality of life

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月18日

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  • Xinyi Tian,
  • Shijiao Yan,
  • Chuanzhu Lv,
  • Xingyue Song,
  • Juntao Wang,
  • Wenjie Hao,
  • Lanfen He,
  • Yu Chen,
  • Yanlan Hu

摘要

Background

Snakebite envenoming remains poorly understood in terms of long-term health-related quality of life (HRQoL), particularly in China where standardized assessments are lacking. This study is the first to comprehensively evaluate HRQoL impairments in discharged snakebite patients using the EuroQol 5-Dimension 5-Level (EQ-5D-5 L) instrument in China, addressing a critical methodological gap.

Methods

A multicenter cross-sectional study enrolled 6,528 snakebite patients. HRQoL was assessed via EQ-5D-5 L (Chinese value set) and customized surveys. Generalized linear models and XGBoost machine learning identified predictors.

Results

The mean utility score (0.76 ± 0.27) was significantly lower than China’s general population (0.95). Pain/discomfort (53.6%) and mobility impairment (45.4%) were most prevalent. Machine learning revealed key predictors: post-traumatic stress disorder (PTSD, 34.5%) > number of snakebites (11.7%) > time of arrival at medical institutions (7.9%) > depression (7.8%) > marriage (6.5%).

Conclusions

This study provides the first EQ-5D-5 L-based quantification of the significant HRQoL burden among snakebite survivors in China. Physical impairments predominantly manifest in the mobility and pain/discomfort dimensions, while mental health disorders constitute the primary driver of long-term HRQoL deterioration. Crucially, we identified PTSD, time to medical facility, and bite frequency as modifiable predictors, evidencing their relevance for snakebite prevention and control strategies.