Scholarlink

Background <p>Severe malarial anaemia and cerebral malaria can result in long-term cognitive, behavioral, and mental health impairments that may influence future household wealth. However, the magnitude and mechanisms of this impact on wealth remain unclear. We assessed the association between different forms of severe malaria and household wealth, 4 to 20 years after the episode.</p> Methods <p>Data were obtained from children previously enrolled in three prospective cohort studies with one of five forms of severe malaria: cerebral malaria (CM; cohorts 1, 2, and 3), severe malarial anaemia (SMA; cohorts 2 and 3), and malaria with respiratory distress, complicated seizures, or prostration (cohort 3). Community children (CC) from the prior studies served as the reference group. Regression analyses assessed the association between forms of severe malaria types and current household socioeconomic index (SEI).</p> Results <p>996 participants and their households were included in the analyses: CM (<i>n</i> = 237), SMA (<i>n</i> = 257), other severe malaria (<i>n</i> = 238), and CC (<i>n</i> = 264). In a regression model including children from cohorts 1, 2 and 3 with CM or SMA, compared to CC, we found that households of children with SMA but not CM had lower SEI than CC (mean difference [95% CI]): SMA, -0.15 (-0.30, -0.01), <i>p</i> = 0.046, at an average of 10.1 years (SD 3.4) following the childhood severe malaria episode. In a regression model for cohort 3, comparing children in this cohort with CM, SMA, or other forms of severe malaria to CC, SMA was the only form of severe malaria associated with lower household SEI compared to CC in unadjusted analysis, and no severe malaria groups was associated with lower household SEI compared to CC after adjustment for household characteristics.</p> Conclusions <p>Our findings indicate that severe malarial anaemia in childhood, but not other forms of severe malaria, may be associated with decreased household wealth 4 to 20 years later. Controlling malaria in low-resource settings could protect poor households from worse socioeconomic index over time.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Severe malarial anaemia in childhood is associated with decreased long-term household wealth

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月25日

查看全文
  • Perez N. Ochanda,
  • Arild Aakvik,
  • Paul Bangirana,
  • Dibyadyuti Datta,
  • Kagan A. Mellencamp,
  • Chandy C. John,
  • Bjarne Robberstad

摘要

Background

Severe malarial anaemia and cerebral malaria can result in long-term cognitive, behavioral, and mental health impairments that may influence future household wealth. However, the magnitude and mechanisms of this impact on wealth remain unclear. We assessed the association between different forms of severe malaria and household wealth, 4 to 20 years after the episode.

Methods

Data were obtained from children previously enrolled in three prospective cohort studies with one of five forms of severe malaria: cerebral malaria (CM; cohorts 1, 2, and 3), severe malarial anaemia (SMA; cohorts 2 and 3), and malaria with respiratory distress, complicated seizures, or prostration (cohort 3). Community children (CC) from the prior studies served as the reference group. Regression analyses assessed the association between forms of severe malaria types and current household socioeconomic index (SEI).

Results

996 participants and their households were included in the analyses: CM (n = 237), SMA (n = 257), other severe malaria (n = 238), and CC (n = 264). In a regression model including children from cohorts 1, 2 and 3 with CM or SMA, compared to CC, we found that households of children with SMA but not CM had lower SEI than CC (mean difference [95% CI]): SMA, -0.15 (-0.30, -0.01), p = 0.046, at an average of 10.1 years (SD 3.4) following the childhood severe malaria episode. In a regression model for cohort 3, comparing children in this cohort with CM, SMA, or other forms of severe malaria to CC, SMA was the only form of severe malaria associated with lower household SEI compared to CC in unadjusted analysis, and no severe malaria groups was associated with lower household SEI compared to CC after adjustment for household characteristics.

Conclusions

Our findings indicate that severe malarial anaemia in childhood, but not other forms of severe malaria, may be associated with decreased household wealth 4 to 20 years later. Controlling malaria in low-resource settings could protect poor households from worse socioeconomic index over time.