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Objective <p>Our study prospectively assessed the relationship between cumulative handgrip strength and temporal changes in depressive symptoms among adults aged 50 years and over.</p> Methods <p>This study was conducted based on two longitudinal cohort studies: the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE). Cumulative handgrip strength was derived from three repeated measurements taken over eight years (ELSA) or six years (SHARE). The mixed linear regression models and Cox regression models were employed to assess the associations between cumulative handgrip strength and temporal changes in depressive symptoms, as well as incident depression risk.</p> Results <p>Participants in the lowest quartile of cumulative handgrip strength had higher depressive symptom scores compared to those in the highest quartile in ELSA (<i>β</i>: 0.191; 95% CI: 0.035, 0.348) and SHARE (<i>β</i>: 0.391; 95% CI: 0.267, 0.514), and experienced an accelerated increase in depressive symptoms of 0.040 point/y (95% CI: 0.009, 0.070) in ELSA, and 0.067 point/y (95% CI: 0.045, 0.089) in SHARE during follow-up. Regarding incident depression, the lowest quartile group faced a 55% (HR: 1.55; 95% CI: 1.13, 2.12) and 62% (HR: 1.62; 95% CI: 1.38, 1.90) increased risk of developing depression in ELSA and SHARE, relative to the highest quartile.</p> Conclusions <p>Reduced cumulative handgrip strength correlated with accelerated depressive symptom progression and increased depression incidence. Future interventional studies should further investigate if strength/muscular fitness can improve mental health, particularly in older adults.</p>

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Cumulative handgrip strength and trajectories of depressive symptoms in older adults: evidence from two cohort studies

  • 期刊论文

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  • 发表日期：

    2025年10月10日

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  • Qingping Xue,
  • Kuifang Guo,
  • Xue Yang,
  • Jieru Peng,
  • Mei Xiong,
  • Yachao Li,
  • Yang Gao

摘要

Objective

Our study prospectively assessed the relationship between cumulative handgrip strength and temporal changes in depressive symptoms among adults aged 50 years and over.

Methods

This study was conducted based on two longitudinal cohort studies: the English Longitudinal Study of Ageing (ELSA) and the Survey of Health, Ageing and Retirement in Europe (SHARE). Cumulative handgrip strength was derived from three repeated measurements taken over eight years (ELSA) or six years (SHARE). The mixed linear regression models and Cox regression models were employed to assess the associations between cumulative handgrip strength and temporal changes in depressive symptoms, as well as incident depression risk.

Results

Participants in the lowest quartile of cumulative handgrip strength had higher depressive symptom scores compared to those in the highest quartile in ELSA (β: 0.191; 95% CI: 0.035, 0.348) and SHARE (β: 0.391; 95% CI: 0.267, 0.514), and experienced an accelerated increase in depressive symptoms of 0.040 point/y (95% CI: 0.009, 0.070) in ELSA, and 0.067 point/y (95% CI: 0.045, 0.089) in SHARE during follow-up. Regarding incident depression, the lowest quartile group faced a 55% (HR: 1.55; 95% CI: 1.13, 2.12) and 62% (HR: 1.62; 95% CI: 1.38, 1.90) increased risk of developing depression in ELSA and SHARE, relative to the highest quartile.

Conclusions

Reduced cumulative handgrip strength correlated with accelerated depressive symptom progression and increased depression incidence. Future interventional studies should further investigate if strength/muscular fitness can improve mental health, particularly in older adults.