<p>Hypertension and type 2 diabetes mellitus are a pair of prevalent chronic non-communicable ailments that present significant obstacles to the global well-being of the public. The study investigates the burden of Hypertension and Type 2 Diabetes in Tamale metropolis. The target population used for the study was all outpatients from the Tamale Teaching Hospital. Secondary source of data was employed for the study. The findings reveal significant variations in hypertension prevalence across demographic categories, with the highest rates found in the 55–64 age group at 31.4% (95% CI: 26.3%—36.5%) and all age groups demonstrating statistical significance (<i>p</i> &lt; 0.0001). Findings further show the prevalence of Type 2 diabetes peaks at 28.8% in the 65–74 age group, while the 25–34 age range has the lowest rate at 1.5%. Findings from the regression analysis reveal that gender and patients’ place of residence significantly influence type 2 diabetes, while age is the only variable that shows a statistically significant association with hypertension. The study concluded that Type 2 diabetes and hypertension is prevalent among older age, higher weight, male gender, self-employed, and lower education. The study recommends for implementation of targeted screening programs focusing on older adults, especially females, and those in self-employed, for Type 2 diabetes and Hypertension.</p>