Background <p>The COVID-19 pandemic has had a profound effect on the mental well-being of individuals, particularly among the youth. The experience of stressful life events has been linked to increased poor mental health. While the immediate effects have been documented, there is evidence to suggest that the pandemic’s impact on mental health could persist in the long run. Additionally, the pandemic has influenced coping strategies and forms of social support.</p> Methods <p>A phenomenological descriptive study was conducted to elucidate the changes in strategies adopted by youth to cope with stressful life events during the COVID-19 era. Thirty-three Chinese youths aged 15 to 24 years who have experienced regular COVID-19 pandemic prevention and control were invited to complete a semi-structured interview. Colaizzi’s method was used to analyze the data. Triangulation was adopted to ensure the validity.</p> Results <p>Four key themes were generated, including (1) negative changes in mental health, (2) positive changes in mental health, (3) changes in the adoption of coping strategies, and (4) the utilization of internet-based coping strategies.</p> Conclusions <p>The results could guide the development of interventions to help the youth cope with stressful life events and further promote mental health among this population.</p> Trial registration <p>This study has prospectively been registered on the Chinese Clinical Trial Registry (ID: ChiCTR2200060894) on 14/06/2022.</p>